Wound healing in mammals and amphibians: Toward perfect skin regeneration in mammals
Project/Area Number |
24770200
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Developmental biology
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Research Institution | The Institute of Physical and Chemical Research (2014) Tohoku University (2012-2013) |
Principal Investigator |
KAWASUMI Aiko 独立行政法人理化学研究所, 生命システム研究センター, 研究員 (80625484)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 創傷治癒 / 真皮再生 / 瘢痕 / マウス胚 / マイクロサージャリー / マクロファージ |
Outline of Final Research Achievements |
Amphibian wound healing, in which blastema cells that express Prrx1 emerge as dedifferentiated cells, leads to a perfect restoration of tissue architecture and function. In this study, I found that mouse embryos at e13.5-e15.5 had a capacity to regenerate dermis after wounding, but wound healing in embryos at e16.5-e18.5 resulted in scar formation, as well as neonates and adults. The regenerating dermis (wounds at e13.5-e15.5) express Prrx1, but the incomplete healing dermis (wounds at e16.5-17.5, neonates and adults) doesn't. In addition, there is a little macrophages in the regenerating dermis, but a lot of macrophages in the incomplete healing dermis.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Wound Healing in Mammals and Amphibians: Toward Limb Regeneration in Mammals2013
Author(s)
Kawasumi, A., Sagawa, N., Hayashi, S., Yokoyama, H., and Tamura, K.
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Journal Title
Current Topics in Microbiology and Immunology
Volume: 367
Pages: 33-49
DOI
ISBN
9783642358098, 9783642358104
Related Report
Peer Reviewed
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