Analysis of coordinated regulation of metabolism and ovarian development in Drosophila

• Project/Area Number: 24770203
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Developmental biology
• Research Institution: Kurume University
• Principal Investigator: SANO Hiroko 久留米大学, 分子生命科学研究所, 講師 (90506908)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: ショウジョウバエ / 脂肪組織 / インシュリン / エクジソン / 生殖幹細胞ニッチ / 内分泌 / 生殖巣形成

Research Abstract

We have studied the mechanisms as to how the Drosophila adipose tissues regulate ovarian development aiming at clarifying coordinated regulation of metabolism and development. In this study, we found that adipose tissue-derived Insulin (Dilp6) and steroid hormone (20-hydroxyecdysone) regulate the formation of terminal filament, which functions as a part of germline stem cell niche in the ovary.

Research Products

• [Journal Article] Isolation of the bioactive peptides CCHamide-1 and CCHamide-2 from Drosophila and their putative role in appetite regulation as ligands for G protein-coupled receptors (2012)
  • Author(s): Ida, T., Takahashi, T., Tominaga, H., Sato, T., Sano, H., Kume, K., Ozaki, M., Hiraguchi, T., Shiotani, H., Terajima, S., Nakamura, Y., Mori, K., Yoshida, M., Kato, J., Murakami, N., Miyazato, M., Kangawa, K., and Kojima, M.
  • Journal Title: F rontires in Endocrinology Volume: 3 Pages: 177-177
• [Journal Article] The Drosophila actin regulator ENABLED regulates cell shape and orientation during gonad morphogenesis (2012)
  • Author(s): Sano, H., Renault, A., Kunwar, P.S., Barbosa, V., Clark, B.N., Ishihara, S., Sugimura, K., and Lehmann, R.
  • Journal Title: PLoS One Volume: 7
• [Journal Article] Isolation of the bioactive peptides CCHamide-1 and CCHamide-2 from Drosophila and their putative role in appetite regulation as ligands for G protein-coupled receptors. (2012)
  • Author(s): Ida T, Takahashi T, Tominaga H, Sato T, Sano H, Kume K, Ozaki M, Hiraguchi T, Shiotani H, Terajima S, Nakamura Y, Mori K, Yoshida M, Kato J, Murakami N, Miyazato M, Kangawa K, Kojima M.
  • Journal Title: Front Endocrinol. Volume: 3 Pages: 177-177
  • Peer Reviewed
• [Journal Article] The Drosophila actin regulator ENABLED regulates cell shape and orientation during gonad morphogenesis. (2012)
  • Author(s): Sano H, Kunwar PS, Renault AD, Barbosa V, Clark IB, Ishihara S, Sugimura K, Lehmann R.
  • Journal Title: PLoS One Volume: 7
  • Peer Reviewed
• [Presentation] Analysis of the fat body-derived peptide CCHamide-2 in Drosophila (2013)
  • Author(s): Sano, H., Ishimoto, H., Kamikouchi, A., Nakamura, A., Texada, M., Truman, J., Ida, T., and Kojima, M.
  • Organizer: 第36回日本分子生物学会
  • Place of Presentation: 神戸
• [Presentation] Analysis of the peripheral tissue-derived peptides, CCHamide-1 and -2, and dRYamide-1 and -2 in Drosophila (2013)
  • Author(s): Sano, H., Ida, T., and Kojima, M.
  • Organizer: Insect Hormones (19^<th> Ecdysone) International Workshop
  • Place of Presentation: Minneapolis, USA
• [Presentation] Analysis of the peripheral tissu-derived peptides, CCHamide-1 and -2, and dRYamide-1 and -2, in Drosophila (2013)
  • Author(s): Sano, H., Ida, T., and Kojima, M.
  • Organizer: Insect Hormones (19th Ecdysone) International Workshop, 2013
  • Place of Presentation: Minneapolis, USA
• [Presentation] Analysis of the fat body-derived peptide CCHamide-2 in Drosophila (2013)
  • Author(s): Sano, H., Ishimoto, H., Kamikouchi, A., Nakamura, A., Texada, M., Truman, J., Ida, T., and Kojima, M.
  • Organizer: 第36回 日本分子生物学会
  • Place of Presentation: Kobe, Japan
• [Presentation] Nutrition-dependent control of ovarian development by the fat body in Drosophila (2012)
  • Author(s): Reiko Amikura, Makoto Umemori, Ryusuke Niwa, Yuko Shimada-Niwa, Sora Enya, Naoki Okamoto, Takashi Nishimura, and Hiroko Sano
  • Organizer: The 58th/60th NIBB Conference
  • Place of Presentation: Okazaki, Japan
• [Presentation] Control of ovarian development by the fat body in Drosophila (2012)
  • Author(s): Reiko Amikura, Makoto Umemori, Ryusuke Niwa, Yuko Shimada-Niwa, Sora Enya, Naoki Okamoto, Takashi Nishimura, and Hiroko Sano
  • Organizer: Germ Cell Meeting
  • Place of Presentation: CSHL, USA
• [Remarks]
  • URL: http://www.lsi.kurume-u.ac.jp/molecular_genetics/index.html
• [Remarks] 久留米大学分子生命科学研究所 遺伝情報研究部門 ホームページ
  • URL: http://www.lsi.kurume-u.ac.jp/molecular_genetics/index.html