The mechanism of chromatin modifications that establish and maintain germline property
| Project/Area Number |
24770211
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | Kobe University |
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Principal Investigator |
TAKASAKI Teruaki 神戸大学, 理学(系)研究科(研究院), 助教 (30615539)
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| Research Collaborator |
ANDREAS Rechtsteiner University of California, Santa Cruz, Bioinformatist
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 生殖細胞 / クロマチン / ヒストン修飾 / エピジェネティクス / 線虫C. elegans / クロモドメイン / 線虫C.elegans |
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| Outline of Final Research Achievements |
To understand the molecular mechanism that establishes and maintains germline property, we analyzed chromatin modifiers in the nematode C. elegans. We found that the chromodomain protein MRG-1 acts as an interpreter of histone methylation and promotes histone acetylation, generating a unique histone modification pattern on the germline gene-specific loci. We also found that MRG-1 is involved in preventing transcription in premature primordial germ cells. In addition, we revealed an mRNA stability control that restricts maternally supplied chromatin modifiers in primordial germ cells.
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Report
(4 results)
Research Products
(15 results)
