Roles of fibronectin dynamics in tissue remodeling

• Project/Area Number: 24770215
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Developmental biology
• Research Institution: Kumamoto University
• Principal Investigator: SATO Yuki 熊本大学, 大学院先導機構, 助教 (90508186)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 細胞外基質 / フィブロネクチン / イメージング / 体節 / 内胚葉 / 仮足形成 / 上皮細胞 / 細胞外マトリクス / ファイブロネクチン / 背側大動脈

Research Abstract

This study was aimed at further understanding the mechanisms of tissue morphogenesis from the perspective of cell behaviors and substrate patterning. Fibronectin (FN) fibrils are characteristically patterned between somites, endoderm, and notochord. We investigated the specific role of patterned FN fibrils in cell behaviors, mechanisms underlying patterned FN deposition, and molecules involved in substrate-cell interaction by time-lapse imaging analysis.

Research Products

• [Journal Article] Transgenesis and imaging in birds, and available transgenic reporter lines. (2013)
  • Author(s): Sato Y, Lansford R
  • Journal Title: Development, Growth and Differentiation Volume: 55 Issue: 4 Pages: 406-421
  • DOI: 10.1111/dgd.12058
  • NAID: 40019734988
  • Peer Reviewed
• [Journal Article] Dorsal aorta formation: Separate origins, lateral-to-medial migration, and remodeling. (2013)
  • Author(s): Sato Y.
  • Journal Title: Development, Growth and Differentiation Volume: 55 Issue: 1 Pages: 113-129
  • DOI: 10.1111/dgd.12010
  • NAID: 40019549294
  • Peer Reviewed
• [Journal Article] トランスジェニックウズラ胚を用いた血管のタイムラプス観察 (2012)
  • Author(s): 佐藤有紀
  • Journal Title: 顕微鏡 Volume: 47巻4号 Pages: 186-190
  • NAID: 10031144736
  • URL: http://www.microscopy.or.jp/magazine/47_4/mokuji.html
  • Peer Reviewed
• [Journal Article] トランスジェニックウズラ胚を用いた血管のタイムラプス観察 (2012)
  • Author(s): 佐藤 有紀
  • Journal Title: 顕微鏡 Volume: 47 Pages: 619-643
  • NAID: 10031144736
  • Peer Reviewed
• [Presentation] トランスジェニックウズラ胚を用いた血管のライブイメージング解析 (2013)
  • Author(s): Sato Y, Huss D, Lansford R.
  • Organizer: 第1回ウズラ研究会
  • Place of Presentation: 名古屋大学
  • Year and Date: 2013-12-10
• [Presentation] 血管および体節の形態形成を支える細胞群のふるまい (2013)
  • Author(s): 佐藤有紀
  • Organizer: 日本動物学会第84回大会
  • Place of Presentation: 岡山大学
• [Presentation] Role of somitic cell protrusions in the paraxial tissue morphogenesis (2013)
  • Author(s): Sato Y., Nagatoshi K., Imamura Y., Hamano A., Uchida S.
  • Organizer: CMCB congress
  • Place of Presentation: Suzhou International Expo Center, China
• [Presentation] Role of somitic cell protrusions in the paraxial tissue morphogenesis (2013)
  • Author(s): Sato Y., Nagatoshi K., Imamura Y., Hamano A., Uchida S.
  • Organizer: CMCB congress
  • Place of Presentation: Suzhou International Expo Center （中国）
  • Invited
• [Presentation] トランスジェニックウズラ胚を用いた血管のライブイメージング解析 (2013)
  • Author(s): Sato Y., Huss D., Lansford R.
  • Organizer: 第１回ウズラ研究会
  • Place of Presentation: 名古屋大学
• [Presentation] Dynamic imaging analysis of blood vessel formation in transgenic quail embryo (2012)
  • Author(s): Sato Y, Huss D, Poynter G, Fraser S.E, Lansford R.
  • Organizer: 20th Annual Meeting of the Japanese Vascular Biology and Medicine Organization
  • Place of Presentation: Awagin Hall, Tokushima, Japan
  • Year and Date: 2012-12-07
• [Presentation] 血管形成を支える細胞の動き (2012)
  • Author(s): 佐藤有紀、ラスティーランスフォード
  • Organizer: 第22回日本数理生物学会
  • Place of Presentation: 岡山大学
  • Year and Date: 2012-09-12
• [Presentation] Role of somitic filopodia in the collective morphpgenesis of paraxial tissues (2012)
  • Author(s): Sato Y, Nagatoshi K.
  • Organizer: 7th International Chick Meeting
  • Place of Presentation: Nagoya University, Japan
• [Presentation] Role of somitic filopodia in the collective morphpgenesis of paraxial tissues (2012)
  • Author(s): Sato Y, Nagatoshi K.
  • Organizer: Joint Meeting of the 45th Annual Meeting of the Japanese Society for Developmental Biologists & the 64th Annual Meeting of the Japanese Society for Cell Biology
  • Place of Presentation: Kobe International Conference Center, Japan
• [Presentation] Role of somitic filopodia in the collective morphogenesis of paraxial tissues (2012)
  • Author(s): Yuki Sato and Kei Nagatoshi
  • Organizer: Joint Meeting of the 45th Annnual Meeting of the Japanese Society of Developmental Biologists & the 64th Annual Meeting of the Japan Society for Cell Biology
  • Place of Presentation: 神戸国際会議場
  • Invited
• [Presentation] 血管形成を支える細胞の動き (2012)
  • Author(s): 佐藤 有紀、ラスティー ランスフォード
  • Organizer: 第22回 日本数理生物学会大会
  • Place of Presentation: 岡山大学
  • Invited
• [Presentation] Role of somitic filopodia in the collective morphogenesis of paraxial tissues (2012)
  • Author(s): Yuki Sato and Kei Nagatoshi
  • Organizer: The 7th International Chick Meeting
  • Place of Presentation: 名古屋大学
• [Presentation] Dynamic imaging analysis of blood vessel formation in transgenic quail embryo (2012)
  • Author(s): Yuki Sato, David Huss, Greg Poynter, Scott E. Fraser, and Rusty Lansford
  • Organizer: The 20th Annual Meeting of the Japenese Vascular Biology and Medicine Organization
  • Place of Presentation: あわぎんホール
  • Invited
• [Remarks]
  • URL: http://bloodvesseldynamics.jp/
• [Remarks] 熊本大学 大学院先導機構 佐藤有紀研究室
  • URL: http://bloodvesseldynamics.jp/
• [Remarks] 熊本大学 佐藤研究室
  • URL: http://bloodvesseldynamics.jp/