Analysis of body axis formation of mouse postimplantation development
Project/Area Number |
24770219
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Developmental biology
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Research Institution | Institute of Physical and Chemical Research |
Principal Investigator |
SHIOI Go 独立行政法人理化学研究所, 発生・再生科学総合研究センター, 専門職研究員 (60391968)
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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Keywords | 前後軸形成 / 胚培養 / ライブイメージング / レポーターマウス / 細胞挙動 / 全胚培養 |
Research Abstract |
To reveal the mechanism of the anterior-posterior (A-P) axis formation in a mouse embryo, the expression pattern of head organizer genes have been reexamined. I found that OTX2 gene was asymmetrically expressed from the very beginning of their expression. The gene which makes Otx2 express asymmetrically might have an important role to develop A-P axis. I also established a culture system of mouse embryos for live-imaging experiments. Then, the behavior of each embryonic visceral endoderm cell during the A-P axis formation has been examined by live-imaging experiments. I found some characteristic cell behaviors which remained to be reported.
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Report
(3 results)
Research Products
(21 results)
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[Presentation] Reporter Mouse Lines for Live Imaging2013
Author(s)
Takaya Abe, Hiroshi Kiyonari, Go Shioi, Kenichi Inoue, Kazuki Nakao, Shinichi Aizawa, Yasuhide Furuta and Toshihiko Fujimori
Organizer
The 10th NIBB-EMBL Symposium 2013: Quantitative Bioimaging
Place of Presentation
Okazaki Conference Center(愛知)
Related Report
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