The origin and evolution of mammalian sex determination; how is marsupial male determined?

• Project/Area Number: 24770225
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Evolutionary biology
• Research Institution: The Graduate University for Advanced Studies (2013); 大学共同利用機関法人情報・システム研究機構(新領域融合研究センター及びライフサイ (2012)
• Principal Investigator: KATSURA Yukako 総合研究大学院大学, その他の研究科, 研究員 (00624727)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 性決定 / 有袋類 / 国際情報交換

Research Abstract

To understand how marsupial male can be genetically determined, we have investigated molecular evolution and function of male determining gene SRY, and identified testis-expressed genes in marsupials by transcriptome analyses. Based on the molecular evolutionary and biochemical analyses, marsupial (wallabies, koalas and so on) SRY sequences are not conserved well compared to eutherian (humans, mice and so on) SRY, but the function of marsupial SRY is similar to eutherians. This study strongly suggests that marsupial male determining gene is also SRY.

Research Products

• [Journal Article] No Evidence for a Second Evolutionary Stratum During the Early Evolution of Mammalian Sex Chromosomes (2012)
  • Author(s): Katsur a, Y. , Satta, Y.
  • Journal Title: PLoS ONE Volume: 7(10)
• [Journal Article] Evolution of Sex Chromosomes and Genomic Structures (2012)
  • Author(s): Katsur a, Y., Iwase, M., Satta, Y.
  • Journal Title: Current Genomics Volume: 13(2) Pages: 115-123
• [Journal Article] No Evidence for a Second Evolutionary Stratum During the Early Evolution of Mammalian Sex Chromosomes. (2012)
  • Author(s): Yukako Katsura, Yoko Satta
  • Journal Title: PLoS ONE Volume: 7 Issue: 10 Pages: e45488-e45488
  • DOI: 10.1371/journal.pone.0045488
  • NAID: 120006576011
  • Peer Reviewed
• [Journal Article] Evolution of Genomic Structures on Mammalian Sex Chromosomes (2012)
  • Author(s): Yukako Katsura, Mineyo Iwase, Yoko Satta
  • Journal Title: Current Genomics Volume: 13 Issue: 2 Pages: 115-123
  • DOI: 10.2174/138920212799860625
  • NAID: 120006576065
  • Peer Reviewed
• [Presentation] Genomic Structures and Gene Evolution on Mammalian X chromosomes (2013)
  • Author(s): Katsura, Y., Satta, Y.
  • Organizer: Lorne Genome Conference
  • Place of Presentation: Australia
• [Presentation] Genomic Structures and Gene Evolution on Mammalian X Chromosomes. (2013)
  • Author(s): Yukako Katsura, Yoko Satta
  • Organizer: The Congress of The European Society for Evolutionary Biology
  • Place of Presentation: ポルトガル・リスボン
• [Presentation] Genomic Structures and Gene Evolution on Mammalian X Chromosomes. (2013)
  • Author(s): Yukako Katsura, Yoko Satta
  • Organizer: Lorne Genome Conference 2013
  • Place of Presentation: オーストラリア・ローン
• [Presentation] Genomic Structures and Gene Evolution on Mammalian X chromosomes (2012)
  • Author(s): Katsura, Y., Satta, Y.
  • Organizer: Annual Meetings of the Society for Molecular Evolution
  • Place of Presentation: Ireland
• [Presentation] 哺乳類のX染色体のゲノム構造と遺伝子進化 (2012)
  • Author(s): 桂有加子
  • Organizer: 日本遺伝学会第84回大会
  • Place of Presentation: 九州大学
• [Presentation] 哺乳類のX染色体のゲノム構造と遺伝子進化 (2012)
  • Author(s): 桂有加子
  • Organizer: 第14回日本進化学会
  • Place of Presentation: 九州大学
• [Presentation] Genomic Structures and Gene Evolution on Mammalian X Chromosomes. (2012)
  • Author(s): Yukako Katsura, Yoko Satta
  • Organizer: Annual Meetings of the Society for Molecular Biology 2012
  • Place of Presentation: アイルランド・ダブリン
• [Presentation] 哺乳類X染色体のゲノム構造と遺伝子進化 (2012)
  • Author(s): 桂有加子
  • Organizer: 日本遺伝学会第84回大会
  • Place of Presentation: 九州大学
• [Presentation] 哺乳類X染色体のゲノム構造と遺伝子進化 (2012)
  • Author(s): 桂有加子
  • Organizer: 第14回日本進化学会
  • Place of Presentation: 首都大学東京