Study of Y chromosome gene in sex differences of skeletal growth
| Project/Area Number |
24780094
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied biochemistry
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| Research Institution | Ehime University |
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Principal Investigator |
KAZUKI INOUE 愛媛大学, 総合科学研究支援センター, 助教 (60623725)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | Y染色体 / 性差 |
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| Research Abstract |
Males have higher bone mass and larger skeletal size than females. Such gender-specific bone phenotype has considered to be generated by the actions of sex steroid hormones. However, an uncharacterized Y chromosome gene is assumed as a significant factor to form gender-specific bone phenotype from clinical observations of patients mutated in the Growth Controlling region on the Y chromosome. To reveal the biological functions of Y chromosome gene in skeletal systems, we generated Y chromosome gene knockout mice by using a novel method. We revealed that Y chromosome gene regulates male skeletal length by controlling cartilage development. Taken together, the present study has uncovered a molecular basis of gender-specific cartilage development.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Estrogen receptor a in osteocytes regulates trabecular bone fo rmation in female mice.2014
Author(s)
Kondoh S, Inoue K, Igaras hi K, Sugizaki H, Shirode-Fukuda Y, Inoue E, Yu T, Takeuchi JK, Kanno J, Bonewald LF, Imai Y.
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Journal Title
Bone
Volume: 60
Pages: 68-77
DOI
Related Report
Peer Reviewed
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[Journal Article] Vitamin D receptor in osteoblasts is a negative regulator of bone mass control2013
Author(s)
Yamamoto Y, Yoshizawa T, Fukuda T, Shirode-Fukuda Y, Yu T, Sekine K, Sato T, Kawano H, Aihara K, Naka michi Y, Watanabe T, Shindo M, Inoue K, Inoue E, Tsuji N, Hoshino M, Karsenty G, Metzger D, Chambon P, Kato S, Imai Y.
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Journal Title
Endocrinology.
Volume: 154
Issue: 3
Pages: 1008-20
DOI
Related Report
Peer Reviewed
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