Development of the rational method for the synthesis of bioactive cyclic peroxides

Research Project

Project/Area Number	24780110
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Bioproduction chemistry/Bioorganic chemistry
Research Institution	The University of Tokyo
Principal Investigator	MORI NAOKI 東京大学, 農学生命科学研究科, 助教 (60463882)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	oundoperoxide / セスキテルペン / 抗マラリア活性 / okundoperoxide / sesquiterpene / antimalarial / ペルオキシド
Research Abstract	Bioactive cyclic peroxides are expected to be candidates for new drugs such as antimalarial and anticancer agents. I aimed to develop the rational method for the synthesis of these peroxides and studied the synthrsis of okundoperoxide. I developed the stereoselective introduction method of peroxide unit by employing the Diels-Alder reaction between silyl dienyl ether and singlet oxygen. First asymmetric total synthesis of okundoperoxide has also been accomplished by using this method.

Report

(3 results)