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Analysis of the coordinative function between a milk antimicrobial protein and an intestinal epithelial lectin for microbial colonization in the infant intestine

Research Project

Project/Area Number 24780126
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Food science
Research InstitutionNagoya University

Principal Investigator

OSHIMA Kenzi  名古屋大学, 生命農学研究科, 助教 (90391888)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords腸内細菌 / ラクトフェリン / 食品機能
Research Abstract

We suggest a hypothetical model in which anti-bacterial protein lactoferrin (LF), which is ingested as a component of milk, and intestinal protein, intelectin, bind and cooperate to regulate primary intestinal flora development in the infant digestive tract. This study validated this hypothesis and obtained following results. 1) Intelectin partially localized in some specific cellular compartments and affected LF intake by the cultured intestinal epithelial cells. 2) Intelectin and LF differently promoted growth of some Bifidobacterium lines. 3) To analyze interaction between intestinal epithelia and microbes in the culture system, several cell lines with the various characters were isolated from heterogenous HT29 cell line.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2013

All Presentation (2 results)

  • [Presentation] 腸上皮細胞でのラクトフェリンの取り込みおよび細胞内輸送におけるインテレクチンの機能解析2013

    • Author(s)
      加藤元常、小田聖、灘野大太、松田幹、大島健司
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(神戸)
    • Related Report
      2013 Final Research Report
  • [Presentation] 腸上皮細胞でのラクトフェリンの取り込みおよび細胞内輸送におけるインテレクチンの機能解析2013

    • Author(s)
      加藤元常、小田聖、灘野大太、松田幹、大島健司
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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