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Development of a technique to produce hydrogel-based core-shell type micro particles by using the freeze-concentrated phase

Research Project

Project/Area Number 24780132
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Food science
Research InstitutionKyoto University (2013)
University of Hyogo (2012)

Principal Investigator

NAKAGAWA Kyuya  京都大学, (連合)農学研究科(研究院), 准教授 (90433325)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords食品工学 / 凍結濃縮 / マイクロカプセル / ハイドロゲル
Research Abstract

Freeze-concentrated phase is a concentrated liquid phase that forms due to the ice formation, where solutes and suspended matters are to be concentrated. This concentration phenomenon was used to produce nano- microcapsules with unique characteristics. First, we prepared self-aggregated caseinates nanoparticles that encapsulated beta caroteins by hydrophobic interactions. Second, core-shell type nanoparticle with oil core coated by gelatin-acacia complex coacervate. And third, core-shell type nanoparticle with oil core coated by polysaccharide based cryogel. These three types of nanoparticles were prepared via freezing process, and the resultant characteristics were investigated. It was found that the freezing affected to the resultant encapsulation efficiencies, and the selection of freezing protocol enabled to reduce initial burst of the core materials and/or to control release kinetics.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (27 results)

All 2014 2013 2012

All Journal Article (10 results) (of which Peer Reviewed: 4 results) Presentation (15 results) Book (2 results)

  • [Journal Article] Hydrogel Based Oil Encapsulation for Controlled Release of Curcumin by Using a Ternary System of Chitosan, kappa-Carrageenan, and Carboxymethylcellulose Sodium Salt2013

    • Author(s)
      K. Nakagawa, N. Sowasod, W. Tanthapanichakoon and T. Charinpanitkul
    • Journal Title

      LWT Journal of Food Science and Technology

      Volume: 54

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Spray-drying of casein aggregates loaded withβ-carotene : Influences of acidic conditions and storage time on surface structure and encapsulation efficiencies2013

    • Author(s)
      T. Jarunglumlert, K. Nakagawa
    • Journal Title

      Drying Technology

      Volume: 31

    • Related Report
      2013 Final Research Report
  • [Journal Article] Characterization of freeze-dried core-shell nanoparticles prepared via gelatin–acacia complex coacervation : A study on particle formation upon freezing2013

    • Author(s)
      K. Nakagawa
    • Journal Title

      Drying Technology

      Volume: 31

    • Related Report
      2013 Final Research Report
  • [Journal Article] Encapsulation of curcumin loaded oil droplets with chitosan based cryogel : Influence of freezing condition on nanocapsule properties2013

    • Author(s)
      N. Sowasod, K. Nakagawa, W. Tanthapanichakoon and T. Charinpanitkul
    • Journal Title

      Food Science and Technology Research

      Volume: 19

    • NAID

      10031189988

    • Related Report
      2013 Final Research Report
  • [Journal Article] Characterization of casein-based nanoparticles formed upon freezing by in-situ SAXS measurement2013

    • Author(s)
      K. Nakagawa and M. Kagemoto
    • Journal Title

      Colloids and Surfaces B : Biointerfaces

      Volume: 103

    • Related Report
      2013 Final Research Report
  • [Journal Article] Spray-drying of casein aggregates loaded with β-carotene: Influences of acidic conditions and storage time on surface structure and encapsulation efficiencies2013

    • Author(s)
      T. Jarunglumlert, K. Nakagawa
    • Journal Title

      Drying Technology

      Volume: 31 Issue: 13-14 Pages: 1459-1465

    • DOI

      10.1080/07373937.2013.800548

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of freeze-dried core-shell nanoparticles prepared via gelatin–acacia complex coacervation: A study on particle formation upon freezing2013

    • Author(s)
      K. Nakagawa
    • Journal Title

      Drying Technology

      Volume: 31 Issue: 13-14 Pages: 1466-1476

    • DOI

      10.1080/07373937.2013.803197

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Encapsulation of Curcumin Loaded Oil Droplets with Chitosan Based Cryogel: Influence of Freezing Condition on Nanocapsule Properties2013

    • Author(s)
      N. Sowasod, K. Nakagawa, W. Tanthapanichakoon and T. Charinpanitkul
    • Journal Title

      Food Science and Technology Research

      Volume: 19 Issue: 4 Pages: 633-640

    • DOI

      10.3136/fstr.19.633

    • NAID

      10031189988

    • ISSN
      1344-6606, 1881-3984
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of casein-based nanoparticles formed upon freezing by in-situ SAXS measurement2013

    • Author(s)
      K. Nakagawa and M. Kagemoto
    • Journal Title

      Colloids and Surfaces B: Biointerfaces

      Volume: 103 Pages: 366-374

    • DOI

      10.1016/j.colsurfb.2012.10.052

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Microencapsulation of oil droplets using freezing-induced gelatin-acacia complex coacervation2012

    • Author(s)
      K. Nakagawa and H. Nagao
    • Journal Title

      Colloids and Surfaces A : Physicochemical and Engineering Aspects

      Volume: 411

    • Related Report
      2013 Final Research Report
  • [Presentation] A Moderate Structural Change of theβ-Carotene Loaded Sodium Caseinate Aggregates in a Stock Solution2014

    • Author(s)
      K. Nakagawa
    • Organizer
      Food Structure and Functionality Forum Symposium
    • Place of Presentation
      Amsterdam
    • Related Report
      2013 Final Research Report
  • [Presentation] β-Carotene loaded spray-dried sodium caseinate aggregates powder2014

    • Author(s)
      K. Nakagawa, T. Jarunglumlert, S. Adachi
    • Organizer
      6^<th> Training School on Bioencapsulation
    • Place of Presentation
      Nha Trang
    • Related Report
      2013 Final Research Report
  • [Presentation] A Moderate Structural Change of the β-Carotene Loaded Sodium Caseinate Aggregates in a Stock Solution2014

    • Author(s)
      K. Nakagawa
    • Organizer
      Food Structure and Functionality Forum Symposium
    • Place of Presentation
      Amsterdam
    • Related Report
      2013 Annual Research Report
  • [Presentation] β-Carotene loaded spray-dried sodium caseinate aggregates powder2014

    • Author(s)
      K. Nakagawa
    • Organizer
      6th Training School on Bioencapsulation
    • Place of Presentation
      Nha Trang
    • Related Report
      2013 Annual Research Report
  • [Presentation] Gelatin-Acacia-based core-shell nanoparticles formed upon freezing : A processing approach to optimize encapsulation efficiencies2013

    • Author(s)
      K. Nakagawa
    • Organizer
      19^<th> International Symposium on Microencapsulation
    • Place of Presentation
      Pamplona
    • Related Report
      2013 Final Research Report
  • [Presentation] Characterization of the Spray-Dried Casein Aggregates loaded withβ-carotene : A moderate structural modification during storage improves the encapsulation efficiencies2013

    • Author(s)
      T. Jarunglumlert, K. Nakagawa
    • Organizer
      19^<th> International Symposium on Microencapsulation
    • Place of Presentation
      Pamplona
    • Related Report
      2013 Final Research Report
  • [Presentation] Gelatin-Acacia-based core-shell nanoparticles formed upon freezing: A processing approach to optimize encapsulation efficiencies2013

    • Author(s)
      K. Nakagawa
    • Organizer
      19th International Symposium on Microencapsulation
    • Place of Presentation
      Pamplona
    • Related Report
      2013 Annual Research Report
  • [Presentation] Characterization of the Spray-Dried Casein Aggregates loaded with β-carotene: A moderate structural modification during storage improves the encapsulation efficiencies2013

    • Author(s)
      T. Jarunglumlert
    • Organizer
      19th International Symposium on Microencapsulation
    • Place of Presentation
      Pamplona
    • Related Report
      2013 Annual Research Report
  • [Presentation] Gelatin-Acacia-based core-shell nanoparticles formed upon freezing: A processing approach to optimize encapsulation efficiencies2013

    • Author(s)
      K. Nakagawa
    • Organizer
      19th International Symposium on Microencapsulation
    • Place of Presentation
      Pamplona (Spain)
    • Related Report
      2012 Research-status Report
  • [Presentation] CHARACTERIZATION OF THE SPRAY-DRIED CASEIN AGGREGATES LOADED WITH β-CAROTENE: A MODERATE STRUCTURAL MODIFICATION DURING STORAGE IMPROVES THE ENCAPSULATION EFFICIENCIES2013

    • Author(s)
      T. Jarunglumlert and K. Nakagawa
    • Organizer
      19th International Symposium on Microencapsulation
    • Place of Presentation
      Pamplona (Spain)
    • Related Report
      2012 Research-status Report
  • [Presentation] 凍結を利用したカゼイン微粒子の作製とその特性制御に関する研究2012

    • Author(s)
      中川究也,小林敬,安達修二
    • Organizer
      食品工学会第14回年次大会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] 食品マイクロカプセルの機能性とその制御技術2012

    • Author(s)
      中川究也
    • Organizer
      化学工学会高松大会
    • Place of Presentation
      高松
    • Related Report
      2013 Final Research Report
  • [Presentation] Characterization of Freeze-dried Spray-dried Protein-based Nanoparticles Fabricated via Cryoprocessing2012

    • Author(s)
      K. Nakagawa, H. Nagao, M. Kagemoto
    • Organizer
      18^<th> International Drying Symposium (IDS 2012)
    • Place of Presentation
      Xiamen, China
    • Related Report
      2013 Final Research Report
  • [Presentation] 凍結を利用したハイドロゲル微粒子創製技術の検討2012

    • Author(s)
      中川究也,長尾裕充,影本真之
    • Organizer
      食品工学会第13回年次大会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] 凍結を利用したコアシェル型ハイドロゲルナノ粒子の新規作製法2012

    • Author(s)
      中川究也,長尾裕充,影本真之
    • Organizer
      化学工学会第77年会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Book] 凍結を利用してナノカプセル・ナノ粒子の特性を制御する技術,食品素材のナノ加工を支える技術(監修:安達修二・中嶋光孝・杉山滋)2013

    • Author(s)
      中川究也
    • Publisher
      シーエムシー出版
    • Related Report
      2013 Final Research Report
  • [Book] 「食品素材のナノ加工を支える技術」中の「凍結を利用してナノカプセル・ナノ粒子の特性を制御する技術」2013

    • Author(s)
      中川究也
    • Publisher
      シーエムシー出版
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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