Proposal of safety levels of iron intake from the gene expression analysis of the liver and blood of rats fed the iron excess or deficient diet
| Project/Area Number |
24780139
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Kanagawa Academy of Science and Technology |
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Principal Investigator |
KAMEI Asuka 公益財団法人神奈川科学技術アカデミー, 「健康・アンチエイジング」プロジェクト, 研究員 (40514112)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | DNAマイクロアレイ / 鉄欠乏 / 貧血のない鉄欠乏 / 鉄過剰 / 肝臓 / 血液 / 鉄 / 血球細胞 |
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| Research Abstract |
Iron is an essential mineral for the body and its deficient is the problem in the world. In Japan, about 10% of women suffer from iron-deficient anemia, and 20-40% from non-anemic iron deficiency. Iron is also the risk factor of oxidative stress when accumulated in the organs excessively. In this study, by the global analysis of gene expression, a variety of metabolic processes tended to change in the liver of non-anemic iron deficient rats. Also, it was revealed that gene expression patterns in the liver and the blood cells, were changed in rats fed iron-excess diet.
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Report
(3 results)
Research Products
(4 results)
