| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
The comprehensive expression pattern in chub mackerel and blue mackerel were compared by the scombrids-universal microarray to reveal the molecular basis for the differences in disease-resistance traits between this two species belonging to same genus, Scomber. We have previously revealed that blue mackerel showed higher resistance against bacterial disease in the high water temperature periods than chub mackerel in the same temperature condition. As the results of the comparison of the comprehensive gene-expression pattern in the epithelial tissue of the two Scomber species, inflammatory mediators, antimicrobial peptides and the genes related to the acute inflammation showed significantly higher expression in the chub mackerel showed lower resistance against bacterial disease in the high temperature period than blue mackerel. These results suggest that the excessive innate immune response possibly enhance high mortality during high water temperature period.
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