| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Teleosts can change their skin color in response to lighting conditions. Typical hormonal peptides associating color changes are melanin-concentrating hormone (MCH) generated in hypothalamus, melanocyte-stimulating hormone (MSH) generated in pituitary, and agouti-signaling protein (ASP) in skin. These peptides cause color pigments to be dispersed or concentrated, and control the proliferation and maintenance of chromatophores. Shubunkin, a breed of goldfish, has a calico pattern on the skin. This study was undertaken to elucidate the function of these hormonal peptides in the pattern formation of this fish. The results suggested that: 1) specific subtypes of MCH receptor and MSH receptor (MCHR2, MC1R, and MC5R) might have an important role in the proliferation and maintenance of melanophores and xanthophores, and 2) ASP might not be involved in the formation of the calico pattern.
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