| Project/Area Number |
24780205
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Fisheries chemistry
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| Research Institution | Tokai University Junior College |
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Principal Investigator |
HONMA Tomohiro 東海大学短期大学部, その他部局等, 准教授 (90435272)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 深海産イソギンチャク / オヨギイソギンチャク / ペプチド毒 / サワガニ / Naチャネル毒 / Kチャネル毒 / PaTX / 構造活性相関 / Metridin / ShK / サソリ毒 |
|---|
| Outline of Final Research Achievements |
Seven novel peptide toxins from five species of deep-sea anemones, and two novel peptide toxins from one species of shallow-water sea anemones were isolated and their primary structures were analyzed. Furthermore, type 3 sodium channel peptide toxins of sea anemones were focused on because structure-activity relationships of the type 3 had not been clarified thoroughly, compared to type 1 and 2. Amino acid residues, which were considered to be essential for function of type 3 toxins, were specified. These studies revealed that many useful novel peptide toxins, which are not clarified yet, exist in the deep-sea anemones.
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