The study of novel mechanism for oocyte development regulated by signal interaction.

• Project/Area Number: 24780267
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied animal science
• Research Institution: The University of Tokyo
• Principal Investigator: SUGIURA KOJI 東京大学, 農学生命科学研究科, 准教授 (20595623)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 繁殖 / 卵巣卵胞 / 卵母細胞

Research Abstract

This study was conducted to understand the mechanism of oocyte development. Using a microarray method, the effects of oocyte-derived paracrine factors and/or estrogen on the transcriptome of cumulus cells were examined.

Research Products

• [Journal Article] 卵胞発達における卵母細胞由来の増殖因子の役割 (2014)
  • Author(s): 江森千紘、川崎紅、杉浦幸二
  • Journal Title: 日本IVF学会雑誌 Volume: 17巻1号
• [Journal Article] Hormonal Coordination of Natriuretic Peptide Type C and Natriuretic Peptide Receptor 3 Expression in Mouse Granulosa Cells (2013)
  • Author(s): Lee KB, Zhang M, Sugiura K, Wigglesworth K, Uliasz T, Jaffe LA, Eppig JJ
  • Journal Title: Biol. Reprod Volume: 88 Pages: 42-42
  • Peer Reviewed
• [Journal Article] Cooperative effects of 17β-estradiol and oocyte-derived paracrine factors on the transcriptome of mouse cumulus cells (2013)
  • Author(s): Emori C, Wigglesworth K, Fujii W, Naito K, Eppig JJ, Sugiura K
  • Journal Title: Endocrinology Volume: 154 Pages: 4859-4872
  • Peer Reviewed
• [Journal Article] Cooperative effects of 17β-estradiol and oocyte-derived paracrine factors on the transcriptome of mouse cumulus cells. (2013)
  • Author(s): Emori C, Wigglesworth K, Fujii W, Naito K, Eppig JJ, Sugiura K
  • Journal Title: Endocrinology Volume: 154 Issue: 12 Pages: 4859-4872
  • DOI: 10.1210/en.2013-1536
  • Peer Reviewed
• [Journal Article] Role of oocyte-derived paracrine factors in follicular development
  • Author(s): Emori C, Sugiura K
  • Journal Title: Anim. Sci. J Volume: (in press)
• [Presentation] ブタ卵胞液におけるエキソソームの存在確認 (2014)
  • Author(s): 松野雄太,藤井渉,内藤邦彦,杉浦幸二
  • Organizer: 第118回日本畜産学会
  • Place of Presentation: につくば国際会議場
  • Year and Date: 2014-03-28
• [Presentation] マウス個体の老化が卵母細胞と卵丘細胞間のコミュニケーションに及ぼす影響 (2013)
  • Author(s): 川崎紅,藤井渉,内藤邦彦,杉浦幸二
  • Organizer: 第106回日本繁殖生物学会
  • Place of Presentation: 東京農工大学
  • Year and Date: 2013-09-13
• [Presentation] マウス卵母細胞が顆粒膜細胞でのmiR-322発現を抑制する (2013)
  • Author(s): 住友準一,藤井渉,内藤邦彦,杉浦幸二
  • Organizer: 第106回日本繁殖生物学会
  • Place of Presentation: 東京農工大学
  • Year and Date: 2013-09-13
• [Presentation] Oocyte-derived BMP15/GDF9 and Estrogen reciprocally regulate Nog expression in cumulus cells to control intrafollicular BMP signals (2013)
  • Author(s): Emori C, Naito K, Sugiura K
  • Organizer: Annual meeting of society for the study of reproduction
  • Place of Presentation: Montréal, Québec, Canada
• [Presentation] 卵-顆粒膜細胞間コミュニケーション (2013)
  • Author(s): 杉浦幸二
  • Organizer: 第16回 日本IVF学会
  • Place of Presentation: パシフィコ横浜、神奈川県
  • Invited
• [Presentation] マウス卵巣におけるFGFリガンドおよびレセプターの発現解析 (2012)
  • Author(s): 古川最一,西村鷹則,藤井渉,内藤邦彦,杉浦幸二
  • Organizer: 第105回日本繁殖生物学会
  • Place of Presentation: 筑波大学
  • Year and Date: 2012-09-06
• [Presentation] マウス卵胞発達におけるNogginの発現制御および機能解析(IYS-02) (2012)
  • Author(s): 江森千紘,内藤邦彦,杉浦幸二
  • Organizer: 第116回日本畜産学会
  • Place of Presentation: 安田女子大学、広島
  • Year and Date: 2012-03-28
• [Presentation] Cooperative activities of oocyte-derived paracrine factors and estrogen on cumulus cell proliferation and metabolism
  • Author(s): Chihiro Emori, Karen Wigglesworth, Kunihiko Naito, John J. Eppig, and Koji Sugiura.
  • Organizer: Society for the study of reproduction
  • Place of Presentation: アメリカ合衆国、ペンシルバニア州
• [Presentation] Oocyte-derived BMP15/GDF9 and estrogen reciprocally regulate Nog expression in cumulus cells to control intrafollicular BMP signals
  • Author(s): Chihiro Emori, Kunihiko Naito, Koji Sugiura
  • Organizer: Society for the study of reproduction
  • Place of Presentation: カナダ、モントリオール
• [Presentation] マウス卵胞発達過程におけるNogginの発現制御および機能解析
  • Author(s): 江森 千紘，内藤 邦彦， 杉浦 幸二
  • Organizer: 第116回日本畜産学会
  • Place of Presentation: 安田女子大学（広島県）