The role of neurokinin B and dynorphin A in GnRH pulse generation
| Project/Area Number |
24780275
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Applied animal science
|
|---|
| Research Institution | National Institute of Agrobiological Sciences |
|---|
Principal Investigator |
YAMAMURA Takashi 独立行政法人農業生物資源研究所, 動物生産生理機能研究ユニット, 任期付研究員 (60582723)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | パルス状分泌 / ニューロキニン / キスペプチン / GnRH / マイクロダイアリシス / ヤギ / ダイノルフィン |
|---|
| Research Abstract |
It is suggested that neurokinin B (NKB) and dynorphin A (Dyn), which are coexpressed in kisspeptin neurons in the arcuate nucleus (ARC), are involved in gonadotrophin releasing hormone (GnRH) pulse generation. To clarify secretion patterns of NKB and Dyn in ARC, we developed in vivo microdialysis method and measured NKB and Dyn in ARC using goats. We enabled measurement of NKB concentration in ARC and observed fluctuations of NKB levels. Although the concentration fluctuations of NKB were not correlated well with pulsatile GnRH/luteinizing hormone release, these results suggested NKB could be secreted by kisspeptin neurons in ARC and involved in GnRH pulse generation.
|
Report
(3 results)
Research Products
(8 results)
-
-
-
-
[Presentation] 新規κオピオイド受容体拮抗剤の末梢投与がシバヤギGnRHパルスジェネレーター活動におよぼす効果2013
Author(s)
伊藤太祐,中務桂佑,若林嘉浩,山村崇,岡村裕昭,大石真也,野口太朗,藤井信孝,上野山賀久,束村博子,前多敬一郎,松田二子,大蔵聡
Organizer
第106回繁殖生物学会大会
Related Report
-
-
-
-
