Why do MRL mice produce oocytes in their testes - analysis of producing mechanism and fuctional evaluation of testicular oocyte

• Project/Area Number: 24780278
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Basic veterinary science/Basic zootechnical science
• Research Institution: Hokkaido University
• Principal Investigator: OTSUKA Saori 北海道大学, (連合)獣医学研究科, 助教 (10566152)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: 発生・分化 / MRL/MpJマウス / 性分化 / 精巣内卵細胞 / 生殖細胞

Research Abstract

There is only one autosomal causative gene for production of testicular oocytes in MRL/MpJ mice. In addition, the related gene for this phenotype seems to locate on chromosome 15. The fetal testicular oocytes show the similar methylation patterns of histone and DNA to ovarian oocytes at the same age. Furthermore, right testes of fetal and postnatal MRL/MpJ mice contain significantly higher number of testicular oocytes than left testes.

Research Products

• [Journal Article] Genomic analysis of the appearance of testicular oocytes in MRL/MpJ mice (2012)
  • Author(s): Otsuka S, Ichii O, Namiki Y, Sasaki N, Hashimoto Y, Kon Y
  • Journal Title: Mamm Genome Volume: 23 Pages: 741-8
  • NAID: 120005356856
  • Peer Reviewed
• [Journal Article] Genomic analysis of the appearance of testicular oocytes in MRL/Mpj mice. (2012)
  • Author(s): Otsuka s, Ichii O, Namiki Y, Sasaki N, Hashimoto Y, Kon Y.
  • Journal Title: Mammalian Genome Volume: 23 Issue: 11-12 Pages: 741-748
  • DOI: 10.1007/s00335-012-9405-3
  • NAID: 120005356856
  • Peer Reviewed
• [Presentation] Initiation of meiosis in fetal testis of MRL mouse to produce testicular oocytes (2012)
  • Author(s): Saori Otsuka
  • Organizer: The 4^<th> Congress of Asian Association of Veterinary Anatomists
  • Place of Presentation: Phuket Graceland Resort & Spa (Phuket, Thailand)
  • Year and Date: 2012-10-25
• [Presentation] MRLマウス胎子精巣における卵細胞形成過程の解析 (2012)
  • Author(s): 大塚沙織
  • Organizer: 日本解剖学会・第59回東北・北海道連合支部学術集会
  • Place of Presentation: 山形大学(山形県・山形市)
  • Year and Date: 2012-09-22
• [Presentation] MRLマウス胎子精巣における卵細胞形成過程の解析 (2012)
  • Author(s): 大塚沙織、市居 修、佐々木宣哉、橋本善春、遠藤大二、昆 泰寛
  • Organizer: 第58回東北・北海道連合支部学術集会
  • Place of Presentation: 山形大学（山形市）
• [Presentation] Initiation of meiosis in fetal testis of MRL mouse to produce testicular oocytes (2012)
  • Author(s): Saori Otsuka, Osamu Ichii, Nobuya Sasaki, Yoshiharu Hashimoto, Yasuhiro Kon
  • Organizer: The 4th Congress of Asian Association of Veterinary Anatomists
  • Place of Presentation: Phuket Graceland Resort & Spa (Thailand)
• [Remarks]
  • URL: http://www.vetmed.hokudai.ac.jp/organization/anat/index.html
• [Remarks] 北海道大学大学院獣医学研究科 解剖学教室 業績
  • URL: http://www.vetmed.hokudai.ac.jp/organization/anat/achievemnents.html
• [Remarks] 北海道大学大学院獣医学研究科 解剖学教室 研究内容 哺乳類における性分化機構の解明
  • URL: http://www.vetmed.hokudai.ac.jp/organization/anat/research/11%20Sex%20determination.html