| Project/Area Number |
24780286
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Kyushu University |
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Principal Investigator |
YASUO SHINOBU 九州大学, (連合)農学研究科(研究院), 准教授 (30574719)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 光周性 / 情動 / セロトニン / 脳 / マウス / 代謝 / 神経伝達物質 |
|---|
| Research Abstract |
Animals living in temperate zones alter their stress- and mood-related physiology to seasonal changes in the environment by using the photoperiod as a primary cue. In human, seasonal affective disorder (SAD) is marked by depression during specific seasons, generally winter. This study clarified that the brain serotonergic system is regulated by photoperiod through the network between brain and peripheral metabolisms, using a mouse strain that exhibits high depression-like behavior under short photoperiod. Additionally, this study identified the antidepressant-like effect of bright light treatment, which was potentiated by a functional amino acid that has modulatory roles of the circadian clock. These data suggest that photoperiod-induced changes in mood can be regulated by light and nutrition.
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