| Project/Area Number |
24780288
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
IZAWA Takeshi 大阪府立大学, 生命環境科学研究科(系), 助教 (20580369)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 肝硬変 / 鉄代謝障害 / 鉄調節因子 / 鉄代謝 / hepcidin / 炎症 / 動物モデル / miRNA |
|---|
| Research Abstract |
We investigated the molecular mechanism of iron overload, a risk factor of liver cirrhosis. As in humans, iron overload progressed during the progression of cirrhosis in rats, which was accompanied by suppression of hepcidin transcription (a central regulator of iron homeostasis) and inactivation of IL6-STAT3 pathway (an inducer of hepcidin transcription). These data suggests that the impaired hepcidin induction can be involved in the iron overload during progression of cirrhosis.
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