• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular pathology of iron dysregulation during progression of liver cirrhosis

Research Project

Project/Area Number 24780288
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionOsaka Prefecture University

Principal Investigator

IZAWA Takeshi  大阪府立大学, 生命環境科学研究科(系), 助教 (20580369)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords肝硬変 / 鉄代謝障害 / 鉄調節因子 / 鉄代謝 / hepcidin / 炎症 / 動物モデル / miRNA
Research Abstract

We investigated the molecular mechanism of iron overload, a risk factor of liver cirrhosis. As in humans, iron overload progressed during the progression of cirrhosis in rats, which was accompanied by suppression of hepcidin transcription (a central regulator of iron homeostasis) and inactivation of IL6-STAT3 pathway (an inducer of hepcidin transcription). These data suggests that the impaired hepcidin induction can be involved in the iron overload during progression of cirrhosis.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (15 results)

All 2014 2013 2012 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 1 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] M1- and M2-macrophage polarization in rat liver cirrhosis induced by thioacetamide (TAA), focusing on Iba1 and galectin-32014

    • Author(s)
      Wijesundera KK, Izawa T(共同筆頭著者), Tennakoon AH, Murakami H, Golbar HM, Katou-Ichikawa C, Tanaka M, Kuwamura M, Yamate J
    • Journal Title

      Exp Mol Pathol

      Volume: 96(3) Pages: 382-392

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] M1- and M2-macrophage polarization in thioacetamide (TAA)-induced rat liver lesions; a possible analysis for hepato-pathology2014

    • Author(s)
      Wijesundera KK, Izawa T, Murakami H, Tennakoon AH, Golbar HM, Kato-Ichikawa C, Tanaka M, Kuwamura M, Yamate J
    • Journal Title

      Histol Histopathol

      Volume: 29(4) Pages: 497-511

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inflammatory regulation of iron metabolism during thioacetamide-induced acute liver injury in rats2014

    • Author(s)
      Izawa T, Murakami H, Wijesundera KK, Golbar HM, Kuwamura M, Yamate J
    • Journal Title

      Exp Toxicol Pathol

      Volume: 66 Issue: 2-3 Pages: 155-62

    • DOI

      10.1016/j.etp.2013.12.002

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] M1- and M2-macrophage polarization in rat liver cirrhosis induced by thioacetamide (TAA), focusing on Iba1 and galectin-32014

    • Author(s)
      Wijesundera KK, Izawa T, Tennakoon AH, Murakami H, Golbar HM, Kato-Ichikawa C, Tanaka M, Kuwamura M, Yamate J
    • Journal Title

      Exp Mol Pathol

      Volume: in press Issue: 3 Pages: 382-392

    • DOI

      10.1016/j.yexmp.2014.04.003

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inflammatory regulation of iron metabolism during thioacetamide-induced acute liver injury in rats2013

    • Author(s)
      Izawa T, Murakami H, Wijesundera KK, Golbar HM, Kuwamura M, Yamate J
    • Journal Title

      Exp Toxicol Pathol

      Volume: 66(2-3) Pages: 155-162

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of glial fibrillary acidic protein (GFAP)-expressing hepatic stellate cells and myofibroblasts in thioacetamide (TAA)-induced rat liver injury2013

    • Author(s)
      Tennakoon AH, Izawa T, Wijesundera KK, Golbar HM, Tanaka M, Ichikawa C, Kuwamura M, Yamate J
    • Journal Title

      Exp Toxicol Pathol

      Volume: 65(7-8) Pages: 1159-1171

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expressions of Iba1 and galectin-3 (Gal-3) in thioacetamide (TAA)-induced acute rat liver lesions2013

    • Author(s)
      Wijesundera KK, Juniantito V, Golbar HM, Fujisawa K, Tanaka M, Ichikawa C, Izawa T, Kuwamura M, Yamate J
    • Journal Title

      Exp Toxicol Pathol

      Volume: 65(6) Pages: 799-808

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis2013

    • Author(s)
      Uehara T, Ainslie GR, Kutanzi K, Pogribny IP, Muskhelishvili L, Izawa T, Yamate J, Kosyk O, Shymonyak S, Bradford BU, Boorman GA, Bataller R, Rusyn I
    • Journal Title

      Toxicol Sci

      Volume: 132(1) Pages: 53-63

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 食餌性鉄過剰・鉄欠乏によるラット肝臓の病理学的変化2014

    • Author(s)
      井澤武史,宮城伶奈,堀内貴至,桑村充,山手丈至
    • Organizer
      第30回日本毒性病理学会学術集会
    • Place of Presentation
      徳島
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 肝硬変の進展に関わる新規miRNAの病理学的役割の検討2013

    • Author(s)
      堀内貴至,井澤武史,Wijesundera K,桑村充,山手丈至
    • Organizer
      第30回日本毒性病理学会学術集会
    • Place of Presentation
      徳島
    • Related Report
      2013 Final Research Report
  • [Presentation] イヌの肝・胆道系疾患の傾向とその病理学的特徴2013

    • Author(s)
      堀内貴至,井澤武史,井澤敬子,桑村充,山手丈至
    • Organizer
      第155回日本獣医学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 肝硬変の進展に関わる新規miRNAの病理学的役割の検討2013

    • Author(s)
      堀内貴至,井澤武史,Wijesundera K,桑村 充,山手丈至
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜
    • Related Report
      2013 Annual Research Report
  • [Presentation] ラット肝硬変モデルにおける鉄代謝障害の分子メカニズムの解明2012

    • Author(s)
      村上宙,井澤武史,Wijesundera K,Golbar HM,Tennakoon A,桑村充,山手丈至
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      盛岡
    • Related Report
      2013 Final Research Report
  • [Presentation] ラット肝硬変モデルにおける鉄代謝障害の分子メカニズムの解明.2012

    • Author(s)
      村上 宙,井澤武史,Wijesundera K,Golbar HM,Tennakoon A,桑村 充,山手丈至.
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      盛岡
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.vet.osakafu-u.ac.jp/path/path.html

    • Related Report
      2013 Final Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi