Role of 2'-5'-oligoadenylate synthetases in the pathogenicity of flavivirus encephalitis
Project/Area Number |
24780293
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Applied veterinary science
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Research Institution | Hokkaido University |
Principal Investigator |
YOSHII KENTARO 北海道大学, (連合)獣医学研究科, 准教授 (50421988)
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Co-Investigator(Renkei-kenkyūsha) |
KARIWA Hiroaki 北海道大学, 大学院獣医学研究科, 教授 (70224714)
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | フラビウイルス / 脳炎 / OAS / 人獣共通感染症 / OAS / 自然免疫 / インターフェロン / インターフェロンアンタゴニスト |
Research Abstract |
Flaviviruses include many clinically important zoonotic pathogens, and some of them cause severe encephalitis in humans and domestic animals. In study, we showed that congenic mice expressing intact Oas1b can be applied for detailed analysis of pathogenicity of flavivirus encephalitis. Furthermore, we revealed that mutations which arose during adaptation in mammals increased the virulence of tick-borne flaviviruses.
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Report
(3 results)
Research Products
(108 results)
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[Journal Article] Development of a diagnostic method applicable to various serotypes of hantavirus infection in rodents2012
Author(s)
Sanada T, Kariwa H, Saasa N, Yoshikawa K, Seto T, Morozov VG, Tkachenko EA, Ivanov LI, Yoshimatsu K, Arikawa J, Yoshii K, Takashima I
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Journal Title
J Vet Med Sci
Volume: 74
Pages: 1237-1242
NAID
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Peer Reviewed
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[Journal Article] Development of a diagnostic method applicable to various serotypes of hantavirus infection in rodents.2012
Author(s)
Sanada, T., Kariwa, H., Saasa, N., Yoshikawa, K., Seto, T., Morozov, V.G., Tkachenko, E.A., Ivanov, L.I., Yoshimatsu, K., Arikawa, J., Yoshii, K., and Takashima, I.
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Journal Title
The Journal of Veterinary Medical Science
Volume: 74
Pages: 1237-1242
NAID
Related Report
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[Journal Article] Infection of Hantaan virus strain AA57 leading to pulmonary disease in laboratory mice2012
Author(s)
Seto T, Nagata N, Yoshikawa K, Ichii O, Sanada T, Saasa N, Ozaki Y, Kon Y, Yoshii K, Takashima I, Kariwa H
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Journal Title
Virus Research
Volume: 163
Issue: 1
Pages: 284-290
DOI
Related Report
Peer Reviewed
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[Presentation] Characterization of Hokkaido virus, genus hantavirus2012
Author(s)
Sanada, T., Ozaki, Y., Seto, T., Nakao, M., Saasa, N., Yoshimatsu, K., Arikawa, J., Yoshii, K., and Kariwa, H.
Organizer
The 4th International Young Researcher Seminar for Zoonosis Control
Place of Presentation
Sapporo
Year and Date
2012-09-20
Related Report
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[Presentation] Critical Determinant of Neurologic Disease of Tick-borne Flaviviruses2012
Author(s)
Yoshii, K., Sunden, Y., Yokozawa, K., Kariwa, H., Holbrook, M.R., and Takashima, I.
Organizer
46th Joint Working Conference on Viral Diseases, The Japan-United States Cooperative Medical Science Program
Place of Presentation
Beppu
Year and Date
2012-06-20
Related Report
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[Presentation] Critical Determinant of Neurologic Disease of Tick-borne Flaviviruses
Author(s)
Yoshii, K., Sunden, Y., Yokozawa, K., Kariwa, H., Holbrook, M.R., and Takashima, I.
Organizer
46th Joint Working Conference on Viral Diseases, The Japan-United States Cooperative Medical Science Program.
Place of Presentation
別府市B-conプラザ(大分県別府市)
Related Report
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[Presentation] Epidemiology of Hantavirus Infection in Russia and the Establishment of Animal Model for Hantavirus Infection.
Author(s)
Kariwa, H., Seto, T., Yoshikawa, K., Tanikawa, Y., Sanada, T., Saasa, N., Nakamura, I., Yoshimatsu, K., Arikawa, J., Yoshii, K., and Takashima, I.
Organizer
Mini-symposium on Emerging and Re-emerging Viral Diseases in Asia.
Place of Presentation
別府市B-conプラザ(大分県別府市)
Related Report
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[Presentation] Isolation and characterization of hantaviruses from wild rodents and epidemiology of hemorrhagic fever with renal syndrome in Russia
Author(s)
Kariwa, H., Seto, T., Yoshikawa, K., Tanikawa, Y., Sanada, T., Saasa, N., Nakamura, I., Yoshimatsu, K., Arikawa, J., Yoshii, K., and Takashima, I.
Organizer
THE 9th JAPAN-CHINA INTERNATIONAL CONFERENCE OF VIROLOGY
Place of Presentation
北海道大学(北海道札幌市)
Related Report
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[Presentation] The N-terminus of the Montano virus nucleocapsid protein possesses broadly cross-reactive conformation-dependent epitopes conserved in rodent-borne hantaviruses
Author(s)
Saasa, N., Yoshida, H., Shimizu, K., Koma, T., Sanada, T., Seto, T., Yoshii, K., Ramos, C., Yoshimatsu, K., Arikawa, J., Takashima, I., and Kariwa, H.
Organizer
The 4th International Young Researcher Seminar for Zoonosis Control
Place of Presentation
北海道大学(北海道札幌市)
Related Report
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[Presentation] Characterization of Hokkaido virus, genus hantavirus
Author(s)
Sanada, T., Ozaki, Y., Seto, T., Nakao, M., Saasa, N., Yoshimatsu, K., Arikawa, J., Yoshii, K., and Kariwa, H.
Organizer
The 4th International Young Researcher Seminar for Zoonosis Control
Place of Presentation
北海道大学(北海道札幌市)
Related Report
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