| Project/Area Number |
24780294
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied veterinary science
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
SASSA YUKIKO 東京農工大学, (連合)農学研究科(研究院), 助教 (20582464)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 中枢神経系疾患 / 感染症 / 中枢神経系 / アストロサイト |
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| Research Abstract |
The accumulation of abnormal prion protein, degeneration of neurons, astrogliosis and microglial activation are characteristics of prion diseases. By assessing prion-infected mouse brains, astrocyte activation tend to appeare earlier than microbial activation. To analyze the effects of activated astrocytes on neurons are important for understanding the pathogenesis of prion diseases. Then, the astrocytes are focused, especially the localization of abnormal prion protein in astrocytes were analyzed. As a result, the abnormal prion protein were mainly found to be in lysosome in astrocytes.
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