The investigation of the birth of methicillin-resistant Staphylococcus aureus (MRSA) by using genome-wide phylogenetic analysis.
Project/Area Number |
24780298
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Applied veterinary science
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Research Institution | Rakuno Gakuen University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | MRSA / whole-genome sequencing / Staphylococcus sciuri / 次世代シークエンサー / メチシリン耐性遺伝子 / mecA / S. fleurettii / SCCmec |
Outline of Final Research Achievements |
Methicillin-resistant Staphylococcus (S.) aureus (MRSA) is one of the most important multidrug-resistant pathogen of human and animals. The investigation of the birth of MRSA may contribute to more effective control measures for MRSA. In this study, to elucidate the birth of MRSA, we focus on the animal-borne staphylococci, which harbor the origin of the methicillin-resistant gene and its homologues, and performed the whole-genome sequencing and phylogenetic analysis of them. The results suggest the mobile genetic element encoding methicillin-resistance was composed on the chromosome of the animal-borne staphylococci before the element horizontally transferred to the chromosome of S. aureus.
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Report
(4 results)
Research Products
(5 results)
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[Journal Article] Genomic Basis for Methicillin Resistance in Staphylococcus aureus.2013
Author(s)
Hiramatsu K, Ito T, Tsubakishita S, Sasaki T, Takeuchi F, Morimoto Y, Katayama Y, Matsuo M, Kuwahara-Arai K, Hishinuma T, Baba T.
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Journal Title
Infect Chemother
Volume: 45(2)
Issue: 2
Pages: 117-136
DOI
Related Report
Peer Reviewed
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