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Epidemiological investigation on antimicrobial resistance, especially beta-lactam resistance, in Enterobacteriaceae isolated from companion animals

Research Project

Project/Area Number 24780299
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Applied veterinary science
Research InstitutionTottori University

Principal Investigator

Harada Kazuki  鳥取大学, 農学部, 准教授 (80549543)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords薬剤耐性菌 / 伴侶動物 / グラム陰性桿菌 / 微生物 / 獣医学 / 基質拡張型β-ラクタマーゼ / 院内伝播 / 犬 / 腸内細菌 / セファロスポリナーゼ / インテグロン / フルオロキノロン耐性
Outline of Final Research Achievements

In this study, I investigated prevalence of antimicrobial resistance and its epidemiological characteristics in various Gram-negative bacteria isolated from companion animals. Resistance to the tested antimicrobials were less prevalent in Proteus mirabilis and Acinetobacter spp.
In contrast, resistances to antimicrobials including beta-lactams were highly prevalent in Klebsiella spp. and Enterobacter spp. isolated from dogs and cats. Most of beta-lactam-resistant isolates in these bacteria had extended-spectrum beta-lactamases.
These findings suggest that prevalence of antimicrobial resistance can differ by bacterial species. Notably, Klebsiella spp. and Enterobacter spp. are regarded as important antimicrobial-resistant bacteria in veterinary medicine and public health.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (10 results)

All 2016 2015 2014

All Journal Article (3 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Invited: 5 results)

  • [Journal Article] 動物に由来するCTX-M型基質拡張型β-ラクタマーゼ産生大腸菌2015

    • Author(s)
      原田和記、浅井鉄夫
    • Journal Title

      日本化学療法学会雑誌

      Volume: 63 Pages: 181-186

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 国内の伴侶動物における薬剤耐性菌の疫学2015

    • Author(s)
      原田和記
    • Journal Title

      獣医疫学雑誌

      Volume: 19 Pages: 85-90

    • NAID

      130005160222

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Phenotypic and molecular characterization of antimicrobial resistance in Proteus mirabilis isolates from dogs2014

    • Author(s)
      Kazukki Harada, Ayaka Niina, Takae Shimizu, Yujiro Mukai, Ken Kuwajima, Tadashi Miyamoto, Yasushi Kataoka
    • Journal Title

      Journal of Medical Microbiology

      Volume: 63 Issue: 11 Pages: 1561-1567

    • DOI

      10.1099/jmm.0.081539-0

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 国内の伴侶動物由来Klebsiella spp. における薬剤耐性分布2016

    • Author(s)
      原田和記ら
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      日本大学
    • Year and Date
      2016-09-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] 動物におけるESBL産生菌の疫学と公衆衛生リスク2016

    • Author(s)
      原田和記
    • Organizer
      第64回日本化学療法学会総会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2016-06-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 国内の伴侶動物における薬剤耐性菌の疫学.2015

    • Author(s)
      原田和記
    • Organizer
      第45回獣医疫学会学術集会
    • Place of Presentation
      北里大学
    • Year and Date
      2015-09-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 伴侶動物由来細菌の薬剤耐性の疫学(仮題)2015

    • Author(s)
      原田和記
    • Organizer
      第44回日本獣医疫学会学術集会
    • Place of Presentation
      北里大学
    • Year and Date
      2015-09-09
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 伴侶動物から分離されるグラム陰性桿菌の薬剤耐性.2015

    • Author(s)
      原田和記
    • Organizer
      第42回動物用抗菌剤研究会
    • Place of Presentation
      日本獣医生命科学大学
    • Year and Date
      2015-04-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 伴侶動物から分離されるグラム陰性桿菌の薬剤耐性2015

    • Author(s)
      原田和記
    • Organizer
      第42回動物用抗菌剤研究会シンポジウム
    • Place of Presentation
      日本獣医生命科学大学
    • Year and Date
      2015-04-25
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 犬由来Proteus mirabilisにおける薬剤耐性分布とその性状解析2014

    • Author(s)
      原田和記、新名彩加、桑島賢、向井裕次郎、清水孝恵、片岡康
    • Organizer
      第157回日本獣医学会学術集会
    • Place of Presentation
      北海道大学
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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