| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Malignant histiocytosis is a rare disease in humans, where neoplastic histiocytes proliferate uncontrollably. There is currently no known effective treatment option. On the other hand, a similar disease, known as histiocytic sarcoma, is commonly diagnosed in dogs, indicating a ideal naturally occurring tumor model for human's conterpart. Both diaseases are known to cause hyperferritinemia, suggesting that these tumor cells exploit cellular systems to uptake iron molecules, whichi is essential for cells to proliferate. Antimalarial drug artemisinin generate cytotoxic free radicals by racting with iron molecles. This study demonstrated that artemisinin effectively inhibited tumor cell proliferation in several canine cell lines, and explored the relationship between artemisinin-sensitivity of each cell lines and the expression level of proteins related to iron metabolism and uptake.
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