Studies on the involvement in meningioma development of Neospora infection in dogs

Research Project

Project/Area Number	24780308
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Clinical veterinary science
Research Institution	Yamaguchi University
Principal Investigator	ITAMOTO kazuhito 山口大学, 獣医学部, 准教授 (50379921)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords	ネオスポラ / MRI / 髄膜腫 / イヌ
Research Abstract	In this study, we conducted a survey of N.caninum antibody prevalence of patients with neurological symptoms in dogs. Antibody prevalence rate of cases showed neurological symptoms were significantly higher. As a feature on MRI, Dural tail sign was observed in 21/130 cases. Between the meningioma and antibody positive rate of N.caninum that there is a relationship has been suggested. Cases of meningioma is 17 cases in pathology in Search Contact 20 surgery cases. There are the antibody positive in 15 cases. Parasite was not detected in any tissue. Those harvestable of cerebrospinal fluid retrieved in real time PCR and tissue samples five cases, in meningioma cases, but all was not obtained positive cases.