Identification and clinical application of hedgehog signal inhibitors targeting feline mammary cancer stem cells
Project/Area Number |
24780314
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Clinical veterinary science
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Research Institution | Nippon Veterinary and Life Science University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 癌幹細胞 / 猫 / 乳腺腫瘍 / 分子標的薬 / 分子標的治療 |
Research Abstract |
Mammary carcinoma is the third most common cancer in cats. More than 80% of feline mammary tumors show considerable malignancy along with rapid progression and metastasis to the lung and local lymph node at an early stage. For cats with mammary carcinoma, effective chemotherapy is less established. A small population of cells known as tumor-initiating cells, which have the capacity to self-renew, differentiate, and form tumors at high frequency, has a potential role in tumor initiation, aggression, and recurrence. Therefore, novel therapeutic strategies are needed to improve the quality of life in felines with mammary gland tumors. The present results demonstrated that hedgehog inhibitor GDC0449 inhibits sphere formation and ALDH activity, and had antitumor effects in a xenograft model of FKNp, suggesting that anti-tumor-initiating cells therapy with GDC0449 may be useful for treatment of feline mammary carcinoma.
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Report
(3 results)
Research Products
(36 results)
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[Journal Article] Antitumor Effect of Bevacizumab in a Xenograft Model of Canine Hemangiopericytoma2013
Author(s)
Michishita M., Uto T., Nakazawa R., Yoshimura H., Ogihara K., Naya Y., Tajima T., Azakami D., Kishikawa S., Arai T., Takahashi K
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Journal Title
Journal of Pharmacological Sciences
Volume: 21
Pages: 339-342
NAID
Related Report
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[Journal Article] Molecular cloning and tumour suppressor function analysis of canine REIC/Dkk-3 in mammary gland tumours2013
Author(s)
Ochiai K, Watanabe M, Azakami D., Michishita M, Yoshikawa Y., Udagawa C., Metheenukul P., Chahomchuen T., Aoki H., Kumon H., Morimitsum M., Omi T
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Journal Title
The Veterinary Journal
Volume: 197
Pages: 769-775
Related Report
Peer Reviewed
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[Journal Article] Antitumor Effect of Bevacizumab in a Xenograft Model of Canine Hemangiopericytoma2013
Author(s)
Michishita M, Uto T, Nakazawa R, Yoshimura H, Ogihara K, Naya Y, Tajima T, Azakami D, Kishikawa S, Arai T, Takahashi K.
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Journal Title
Journal of Pharmacological Sciences
Volume: 121
Issue: 4
Pages: 339-342
DOI
NAID
ISSN
1347-8613, 1347-8648
Related Report
Peer Reviewed
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