| Project/Area Number |
24780315
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Clinical veterinary science
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| Research Institution | Nippon Veterinary and Life Science University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 下垂体 / ACTH / クッシング症候群 / 11β-HSD |
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| Research Abstract |
It was revealed that the effect of 11beta-HSD inhibitor on dogs was dose-dependent in this study. From the result of our study, it was suggested that ACTH secretion from pituitary was decreased by 11beta-HSD inhibitor in healthy dogs. Moreover, apparent side effects were not observed in the long term administration period of 11beta-HSD inhibitor. We have to research the effect of 11beta-HSD inhibitor on dogs with canine pituitary ACTH adenomas.
In conclusion, we expect that there is possibility that 11beta-HSD inhibitor can be therapeutic drug for canine pituitary ACTH adenoma. Furthermore, we need to proceed this study for treatment of caine pituitary ACTH adenomas.
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