The study of therapy for canine pituitary adenomas by 11beta-HSD inhibitor

Research Project

Project/Area Number	24780315
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Clinical veterinary science
Research Institution	Nippon Veterinary and Life Science University
Principal Investigator	TESHIMA Takahiro 日本獣医生命科学大学, 獣医学部, 助教 (80610708)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	下垂体 / ACTH / クッシング症候群 / 11β-HSD
Research Abstract	It was revealed that the effect of 11beta-HSD inhibitor on dogs was dose-dependent in this study. From the result of our study, it was suggested that ACTH secretion from pituitary was decreased by 11beta-HSD inhibitor in healthy dogs. Moreover, apparent side effects were not observed in the long term administration period of 11beta-HSD inhibitor. We have to research the effect of 11beta-HSD inhibitor on dogs with canine pituitary ACTH adenomas. In conclusion, we expect that there is possibility that 11beta-HSD inhibitor can be therapeutic drug for canine pituitary ACTH adenoma. Furthermore, we need to proceed this study for treatment of caine pituitary ACTH adenomas.