| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The aim of the study is to reveal mechanism of abomasal dismotility that lies behind bovine abomasal displacement (AD) based on smooth muscle contraction. In organ culture model of bovine abomasum, we found medium chain fatty acids activateed Toll-like receptor 4 (TLR4) and enhanced inducible NO synthase (iNOS) and NO production in gastric resident macrophages. Diffused NO affected abomasal smooth muscle dysmotility. Lauric acid was increased in displaced abomasal tissue but not in blood. On the other hand, blood eicosapentaenoic acid (EPA) was decreased, meaning TLR4 signaling by medium fatty acids was enhanced.These results highlight the pathophysiological role of medium fatty acids in AD and also show that the monitoring of blood EPA may contribute for the early diagnosis of AD.
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