Polymer-Supported Chiral Dirhodium(II) Complex for Asymmetric Reactions
| Project/Area Number |
24790001
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Hokkaido University |
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Principal Investigator |
TSUBOWA Koji 北海道大学, 薬学研究科(研究院), 助教 (00572497)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 不斉触媒反応 / ロジウム（II）錯体 / 固相触媒 / ロジウム(II)錯体 |
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| Research Abstract |
(1) A highly effective immobilization of Rh(II) complex has been achieved by copolymerization of dirhodium(II) complex-containing monomer with styrene and flexible cross-linker.
(2) The polymer-supported chiral fluorinated dirhodium(II) complex catalyzed the amination of silyl enol ethers with [N-(2-nitrophenylsulfonyl)imino]phenyliodinane to provide amino ketones in high yields with high levels of enantioselectivity and could be used up to 20 times as the catalyst readily withstood stirring in the presence of the solid reactant.
(3) The polymer-supported chiral chlorinated dirhodium(II) complex promoted intermolecular carbonyl ylide cycloaddition reactions in CF3C6H5 under continuous flow conditions, where high yields as well as high levels of enantioselectivity and turnover number were achieved.
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Report
(3 results)
Research Products
(35 results)
