Innovative Synthetic Studies toward Aminal Alkaloids based on Control of Cascade Oxidative Skeletal Rearrangement
| Project/Area Number |
24790003
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
UEDA HIROFUMI 東北大学, 薬学研究科(研究院), 助教 (50581279)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 有機化学 / 有機合成化学 / 天然物合成化学 / アルカロイド / 酸化反応 / カスケード反応 / 酸化 / ピロロインドール / アミナール / C-H酸化 / 酸化-骨格転位カスケード反応 / 多環性高次構造アルカロイド / ハプロファイチン / グリオクラジン C / 酸素 / グリーンケミストリー / Friedel-Craftsアルキル化 / インドール |
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| Research Abstract |
We focused our attention on syntheses of aminal alkaloids having a densely fused polycyclic skeleton utilizing the cascade oxidative skeletal rearrangement and other original methods found in synthetic studies. As a result of our extensive studies, we successful achieved the total syntheses of haplophytine, isoschizogamine, leuconoxine, gliocladin C, and T988s with novel oxidation reactions developed by our group.
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Report
(3 results)
Research Products
(66 results)
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[Presentation] Synthetic Studies on (-)-Isoschizogamine2013
Author(s)
○Akihiro Takada, Hiroaki Fujiwara, Kenji Sugimoto, Hirofumi Ueda, Hidetoshi Tokuyama
Organizer
International Symposium for the 70th Anniversary of the Tohoku Branch of the Chemical Society of Japan
Place of Presentation
Sendai, Japan
Related Report
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