Synthetic and structure-activity relationship study on a new anticancer agent, yaku'amide A
| Project/Area Number |
24790005
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | ケミカルバイオロジー / ペプチド / 全合成 / ヤクアミド |
|---|
| Research Abstract |
A cytotoxic peptide yaku'amide A was isolated from a marine sponge as an extremely potent cytotoxin. The growth-inhibitory activity of yaku'amide A against a panel of 39 human cancer cell lines is quite unique among known anticancer drugs. Therefore, it is suggested that yaku'amide A possesses new mode of action to exert its bioactivity. In order to evaluate its detailed biological activity, chemical synthesis for supplying material was required.
In this project, the development of a new assembly method of the dehydroamino acid residue utilizing Cu-mediated cross coupling reaction and the first total synthesis of yaku'amide A were achieved. In addition to this, another approach for the synthesis of Z-dehydroamino acid using Staudinger ligation was also established.
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Report
(3 results)
Research Products
(18 results)
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[Presentation] Synthetic Studies on Yaku'amides2012
Author(s)
Takefumi Kuranaga, Yusuke Sesoko, Komei Sakata, Naoya Maeda, Atsushi Hayata, Masayuki Inoue
Organizer
The 7th International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-7)
Place of Presentation
シンガポール
Related Report
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[Presentation] Synthetic Studies on Yaku'amides2012
Author(s)
Takefumi Kuranaga, Yusuke Sesoko, Komei Sakata, Naoya Maeda, Atsushi Hayata, Masayuki Inoue
Organizer
The 7th International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-7) [ The 3rd New Phase International Conference on Cutting-Edge Organic Chemistry in Asia(NICCEOCA-3)]
Place of Presentation
シンガポール
Related Report
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