• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Detection of the reactive oxygen species generated from the photo-irradiation of protoporphyrin IX

Research Project

Project/Area Number 24790006
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Chemical pharmacy
Research InstitutionTokyo Institute of Technology

Principal Investigator

MATSUMURA Yuriko  東京工業大学, 生命理工学研究科, 特任講師 (10439507)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords光線力学的療法 / 活性酸素 / 一重項酸素 / ESR-スピントラッピング法
Outline of Final Research Achievements

In the present study, it was clarified that the super oxide anion radical and carbon radicals were generated with the irradiation of LED light to the Protoporphyrin IX as the photo-sensitizer in addition to the singlet oxygen. it is suggested that the carbon radicals were gnenerated from the oxidation of PpIX by the singlet oxygen. Hydroxyl radicals was generated from the LED irradiation to the cells which contain the endogenous PpIX induced by 5-aminolevulinic acid (ALA).

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (6 results)

All 2015 2014 2013 2012

All Presentation (6 results) (of which Invited: 1 results)

  • [Presentation] ESR-スピントラッピング法を用いた活性酸素計測2015

    • Author(s)
      松村有里子
    • Organizer
      第1回OCU物質科学フロンティアシンポジウム
    • Place of Presentation
      大阪市立大学 理学部会議室
    • Year and Date
      2015-01-09
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 5-アミノレブリン酸の培養細胞に及ぼす影響について2014

    • Author(s)
      松村有里子・岩澤篤郎・小澤俊彦・ 河野雅弘
    • Organizer
      第18階ESRフォーラム研究会
    • Place of Presentation
      名古屋大学 シンポジオン会議室
    • Year and Date
      2014-07-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] ALA共存下で培養したガン細胞から 生成する活性酸素の研究2014

    • Author(s)
      松村有里子・岩澤篤郎・小澤俊彦・ 河野雅弘
    • Organizer
      第4回ポルフィリン・ALA学会年会
    • Place of Presentation
      ニチイ学館・神戸ポートアイランドセンター
    • Year and Date
      2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Analysis of the reactive oxygen species generated by the near ultraviolet LED light irradiation2014

    • Author(s)
      Yuriko Matsumura, Atsuo Iwasawa, Toshihiko Ozawa, Masahiro Kohno
    • Organizer
      17th Biennial Meeting of Society for Free Radical Research International
    • Place of Presentation
      京都国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] Detection of the reactive oxygen species generated from the photo- irradiation of protoporphyrin IX2013

    • Author(s)
      Yuriko Matsumura, Atsuo Iwasawa, Toshihiko Ozawa, Masahiro Kohno
    • Organizer
      1st International ALA and Porphyrin Symposium
    • Place of Presentation
      バーレーン
    • Related Report
      2013 Research-status Report
  • [Presentation] Detection of the reactive oxygen species generated from the photo-irradiation of the photosensitizer used in the photodynamic therapy2012

    • Author(s)
      Yuriko Matsumura, Atsuo Iwasawa, Toshiaki Kamachi, Toshihiko Ozawaa, Masahiro Kohno
    • Organizer
      19th International SPACC Symposium
    • Place of Presentation
      北海道大学
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi