Detection of the reactive oxygen species generated from the photo-irradiation of protoporphyrin IX
| Project/Area Number |
24790006
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | Tokyo Institute of Technology |
|---|
Principal Investigator |
MATSUMURA Yuriko 東京工業大学, 生命理工学研究科, 特任講師 (10439507)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 光線力学的療法 / 活性酸素 / 一重項酸素 / ESR-スピントラッピング法 |
|---|
| Outline of Final Research Achievements |
In the present study, it was clarified that the super oxide anion radical and carbon radicals were generated with the irradiation of LED light to the Protoporphyrin IX as the photo-sensitizer in addition to the singlet oxygen. it is suggested that the carbon radicals were gnenerated from the oxidation of PpIX by the singlet oxygen. Hydroxyl radicals was generated from the LED irradiation to the cells which contain the endogenous PpIX induced by 5-aminolevulinic acid (ALA).
|
Report
(4 results)
Research Products
(6 results)
