Development of Cooperative Chiral NHC Ligand and Catalytic Asymmetric Reactions
| Project/Area Number |
24790011
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
YAMADA Ken-ichi 京都大学, 薬学研究科(研究院), 准教授 (00335184)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 触媒的不斉合成 / キラルカルベン配位子 / キラルNHC |
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| Research Abstract |
To improve the chiral NHC ligand that we developed, steric and electronic effects of substituents were examined. As a result, selectivity in allylic substitution of 1-alkenyl chloride with aryl Grignard reagents was significantly enhanced. In addition, a new cyclization reaction, chiral cyclitol syntheses, kinetic resolution of secondary alcohols were achieved.
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Report
(3 results)
Research Products
(91 results)
