Development of the asymmetric oxidative cyclization using the blessings of nature
| Project/Area Number |
24790015
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
TADA Norihiro 岐阜薬科大学, 薬学部, 講師 (20468234)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 光酸素酸化 / ヨウ素源 / 不斉有機触媒 / 可視光 / 分子状酸素 / 増感剤 |
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| Outline of Final Research Achievements |
I synthesized the new asymmetric organocatalysts from valine, natural amino acid, diaminocyclohexane, and aminopyrrolidine, which efficiently work as catalyst for asymmetric Aldol reaction and Michael addition. I developed asymmetric oxidative lactonization using these asymmetric organocatalysts and commercially available asymmetric organocatalysts combined with molecular oxygen, ultimate oxidizing agent, light, clean energy, and iodine catalyst, abundantly produced in Japan, in moderate yield albeit in low asymmetric yields. Moreover, I developed the flow microreactor for aerobic photooxidation. The oxidative lactonization proceeded using the flow microreactor .
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Report
(4 results)
Research Products
(101 results)
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[Journal Article] Cinchona-diaminomethylenemalononitrile organocatalyst for asymmetric conjugate addition of 1,3-diketone to nitroalkene2014
Author(s)
Hirashima Shin-ichi, Nakashima Kosuke, Fujino Yuki, Arai Ryoga, Sakai Takaaki, Kawada Masahiro, Koseki Yuji, Murahashi Miho, Tada Norihiro, Itoh Akichika, Miura Tsuyoshi
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Journal Title
Tetrahedron Letters
Volume: 55
Issue: 33
Pages: 4619-4622
DOI
Related Report
Peer Reviewed
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