| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Since iron is inexpensive and safe, the development of the novel organic reactions using iron catalyst is valuable. We newly established two type iron-catalyzed reactions. (1) The iron-catalyzed functionalizations of tetrahydrofurans and oxanorbornadiene derivatives accompanied with the ring-opening of carbon-oxygen bonds can provide the pharmaceutically useful skeltones. (2) Although the siloxy and methoxy groups possess the low abilities as leaving groups, we discovered that the siloxy and methoxy groups could be easily eliminated by the use of iron catalyst to give the various products. This methodology is valuable to enable the reduction of cost and synthetic steps.
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