| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
The amide functionality is one of the most fundamental chemical building blocks. It constitutes the backbone of the biological and synthetic materials such as proteins, polymers and pharmaceuticals. In this research, we aimed at the development of catalytic and direct amide formation reaction of carboxylic acid with amine using organoboron. As a result, a series of sulfanyl organoboronic acids has been synthesized. The substituent effect of sulfanyl functional group was demonstrated by amidation of simple carboxylic acid and simple amine.
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