| Project/Area Number |
24790021
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 配糖化 / ワクチンアジュバント / マイクロフローリアクター / 配当化 |
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| Research Abstract |
Against various infection diseases such as Influenza, clinical advance in effective and safety usage of vaccine depends on potent adjuvant. Onjisaponins included in Polygala tenuifolia Willd., were identified. Further drug development of these saponins is hampered by poor isolation yields. Even though synthetic attempt, the problem has been remained for the construction of C28 glycosided bond in oleanolic acid and the introduction of cinnamoyl group.Herein we examined C28 glycosylation as a key step for the synthesis of simple saponin, for purpose of showing their adjuvant activity.
In order to construct simple glucose moiety, chemoselective and regioselective construction of various esters was accomplished. A sensitive C28 glycosyl ester linkage was constructed by using micro flow reactor. In addition, a process for the preparation of tenuifolin, a natural triterpene, was achieved.
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