Development of novel cascade reactions of alkyne derivatives for the efficient synthetic procedures of heterocycles
| Project/Area Number |
24790024
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
SAITO AKIO 東京農工大学, 工学(系)研究科(研究院), 准教授 (10339103)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | アルキン / 複素環 / 金触媒 / ヨウ素試薬 / ヨウ素 / ニトリル / イミダゾール / イソクロマン / オキサゾール / 超原子価ヨウ素 / クロマン |
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| Outline of Final Research Achievements |
We have developed the efficient synthetic methods of heterocyclic compounds by means of cascade reactions and multi-component reactions based on each of the following reactions: 1) syntheses of polycyclic isochromane and benzofuran via Au-catalyzed carboalkoxylation reactions, 2) syntheses of oxazoles and imidazoles by metal-free [2+2+1]annulation reactions, and 3) syntheses of fluorinated oxazoles through hypervalent iodine-mediated cycloisomerization-fluorination reaction.
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Report
(4 results)
Research Products
(31 results)
