Research and development of a novel palladium catalyst

• Project/Area Number: 24790031
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Chemical pharmacy
• Research Institution: Hyogo Medical University
• Principal Investigator: ESAKI Hiroyoshi 兵庫医科大学, 医学部, 講師 (40454889)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: パラジウム / 球状形成活性炭 / 不均一系触媒 / 官能基選択的 / 接触還元 / プロセス化学 / 選択的還元反応 / 球状成形活性炭 / 選択的

Outline of Final Research Achievements

We have developed a highly chemoselective hydrogenation method using a novel and heterogeneous palladium catalyst supported on spherical carbon (Pd/SC) under mild reaction conditions, which is applicable for the hydrogenation of alkyne, alkene, azide, nitro, and aliphatic O-tert-butyldimethylsilyl (TBS) ether functionalities leaving the benzyl ester, benzyl ether, nitrile, aromatic ketone, N-benzyloxycarbonyl (Cbz) protective group, and aromatic O-TBS ether functionalities intact. The present method could accomplish the requirement for both laboratory and industrial applications.

Research Products

• [Journal Article] Chemoselective Hydrogenation Catalyzed by Pd on Spherical Carbon (2013)
  • Author(s): Hiroyoshi Esaki, Tomohiro Hattori, Aya Tsubone, Satoko Mibayashi, Takao Sakata, Yoshinari Sawama, Yasunari Monguchi, Hidehiro Yasuda, Kazuto Nosaka, Hironao Sajiki
  • Journal Title: ChemCatChem Volume: 5 Issue: 12 Pages: 36293635-36293635
  • DOI: 10.1002/cctc.201300639
  • Peer Reviewed
• [Presentation] Palladium on spherical carbon (Pd/SC) as a catalyst for chemoselective hydrogenation (2015)
  • Author(s): Hiroyoshi Esaki, Tomohiro Hattori, Aya Tsubone, Yoshinari Sawama, Yasunari Monguchi, Kazuto Nosaka, Kazuaki Fukushima, Hironao Sajiki
  • Organizer: The International Chemical Congress of Pacific Basin Societies 2015
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2015-12-15 – 2015-12-20
• [Presentation] Highly chemoselective hydrogenation method using Pd on spherical carbon (2014)
  • Author(s): Hiroyoshi Esaki, Tomohiro Hattori, Aya Tsubone, Satoko Mibayashi, Takao Sakata, Yoshinari Sawama, Yasunari Monguchi, Hidehiro Yasuda, Kazuto Nosaka, Hironao Sajiki
  • Organizer: 248th American Chemical Society National Meeting & Exposition
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2014-08-10 – 2014-08-14
• [Presentation] 新規パラジウム触媒を用いた官能基選択的接触還元反応の開発 (2014)
  • Author(s): 江嵜啓祥、服部倫弘、坪根綾、三林聡子、坂田孝夫、澤間善成、門口泰也、保田英洋、野坂和人、佐治木弘尚
  • Organizer: 日本プロセス化学会2014サマーシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2014-07-31 – 2014-08-01
• [Presentation] 球状成形活性炭担持型パラジウムを触媒とした官能基選択的接触還元反応の開発 (2013)
  • Author(s): 江嵜啓祥、服部倫弘、坪根綾、 三林聡子、坂田孝夫、澤間善成、門口泰也、保田英洋、野坂和人、佐治木弘尚
  • Organizer: 第39回反応と合成の進歩シンポジウム
  • Place of Presentation: 九州大学医学部百年講堂
• [Presentation] 球状活性炭担持型パラジウムを触媒とするフロー式接触水素化法 (2012)
  • Author(s): 服部 倫弘、坪根綾、江嵜啓祥、澤間善成、門口泰也、佐治木弘尚
  • Organizer: 第58回日本薬学会東海支部総会・大会
  • Place of Presentation: 静岡県立大学
• [Remarks] 兵庫医科大学化学ホームページ
  • URL: http://www.hyo-med.ac.jp/department/chem/index.html
• [Remarks] 兵庫医科大学化学ホームページ
  • URL: http://www.hyo-med.ac.jp/department/chem/index.html
• [Remarks] 兵庫医科大学化学講座HP
  • URL: http://www.hyo-med.ac.jp/department/chem/