Glycomics for identification of rotavirus receptor and development of antiviral agent
| Project/Area Number |
24790044
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical pharmacy
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| Research Institution | Kinki University |
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Principal Investigator |
YAMADA Keita 近畿大学, 薬学部, 研究員 (80584185)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | ロタウイルス / 硫酸化糖鎖 / N-グリコリルノイラミン酸 / 糖脂質 / 糖鎖アレイ / 分析化学 / NeuGc / 糖鎖構造解析 |
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| Research Abstract |
Rotavirus is the major etiology of severe gastroenteritis in infants especially in developing countries. It is indicated that human rotavirus (hRV) recognizes glycans expressed on host cells as the initial step of virus-cell entry. In this study, glycan structures recognized by hRV were studied by the glycan array method, which we previously established. We found that hRV (MO strain) strongly recognizes NeuGc residues and sulfated glycans. These results indicated that NeuGc and sulfated glycans show an important role in human rotavirus infection.
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Report
(3 results)
Research Products
(26 results)
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[Journal Article] Bovine κ-casein inhibits human rotavirus (HRV) infection via direct binding of glycans to HRV2014
Author(s)
Inagaki, M., Muranishi, H., Yamada, K., Kakehi, K., Uchida, K., Suzuki, T., Yabe, T., Nakagomi, T., Nakagomi, O. and Kanamaru, Y
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Journal Title
Journal of Dairy Science
Volume: 97
Issue: 5
Pages: 2653-2661
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 牛乳由来タンパク質ラクトフォリンの感染阻害作用に関する研究2013
Author(s)
大野翔平,稲垣瑞穂,山田佳太,鈴木徹,松田幹,高橋毅,杉山誠,中込とよ子,中込治,矢部富雄,金丸義敬
Organizer
日本農芸化学会中部支部第168回例会
Place of Presentation
愛知
Year and Date
2013-10-12
Related Report
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[Presentation] The inhibitory mechanism of bovine lactophorin against human rotavirus gastroenteritis2012
Author(s)
Mizuho Inagaki, Shohei Ohno, Keita Yamada, Takeshi Takahashi, Yoshitaka Nakamura, Tsukasa Matsuda, Tomio Yabe, Tohru Suzuki, Makoto Sugiyama, Toyoko Nakagomi, Osamu Nakagomi, and Yoshihiro Kanamaru
Organizer
World Congress of Microbes-2012
Place of Presentation
Guangzhou, China
Year and Date
2012-07-30
Related Report
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