| Project/Area Number |
24790060
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical pharmacy
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
UN Keita 国立医薬品食品衛生研究所, 薬品部, 研究員 (80624535)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | リポソーム / コレカルシフェロール / ドラッグデリバリー / 脂溶性ビタミン / エンドサイトーシス |
|---|
| Research Abstract |
In this study, we determined that cholecalciferol-derivative containing liposomes are interacted with caveolin-1 on the cell surface, and taken up into the cells via caveolae-mediated endocytosis. Moreover, we showed that cholecalciferol-derivative containing liposomes possess the cytotoxic activities, and increase the pharmaceutical activities of the other medicines such as anti-cancer agents. Since the cholecalciferol-derivatives used in this study have already been investigated the metabolic and eliminating process in the body, these components have high biocompatibility. Therefore, these results obtained from this study contribute to pharmaceutical development for the construction of effective and safe medication.
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