Study on a regulation system of intracellular cholesterol transport by ceramide kinase
| Project/Area Number |
24790066
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | セラミドキナーゼ / セラミド-1-リン酸 / 細胞内コレステロール輸送 |
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| Research Abstract |
Ceramide kinase produces the bioactive lipid ceramide-1-phosphate and appears as a key enzyme for regulating cell growth and arachidonic acid metabolism. In this study, to elucidate a novel physiological function, we focused on the transport of intracellular cholesterol. We showed that ceramide kinase is a negative regulator of the cholesterol transport from late endosomes to endoplasmic reticulum.
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Report
(3 results)
Research Products
(36 results)
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[Journal Article] Effects of Hsp90 inhibits, geldanamycin and its analog, on ceramide metabolism and cytotoxicity in PC12 cells2012
Author(s)
Toyomura K, Saito T, Emori S, Matsumoto I, Kato E, Kaneko M, Okuma Y, Nakamura H, Murayama T
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Journal Title
J. Toxicol. Sci.
Volume: 37
Pages: 1049-1057
Related Report
Peer Reviewed
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