Establishment of evaluation methods for molecular targeted anticancer drugs targeting organelle specific stress response in the cell
| Project/Area Number |
24790072
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
HORIBE Tomohisa 京都大学, 医学(系)研究科(研究院), 特定講師 (20467468)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
|
|---|
| Keywords | 薬学 / 癌 / ストレス / タンパク質 |
|---|
| Research Abstract |
To establish the evaluation methods for molecular targeted anticancer drugs targeting organelle specific stress response in cancer cell, reporter vectors using promoter regions of responsive genes for organelle specific unfolded protein response (UPR) were constructed, and then assessed by luminometer and single-cell bioluminescence imaging system. It was confirmed that bioluminescence imaging system at single cell level was available tools for the evaluation methods using the constructed reporter vectors in this study.
|
Report
(3 results)
Research Products
(11 results)
