Analysis for role of calumin in lipid transport of polarized cells

• Project/Area Number: 24790073
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biological pharmacy
• Research Institution: Kyoto University
• Principal Investigator: YAMAMOTO Shinichiro 京都大学, 薬学研究科(研究院), 助教 (10542102)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: ERAD / ER ストレス

Research Abstract

Calumin is a novel ER-resident protein. Disruption of calumin gene in mice causes embryonic lethality, suggesting that calumin plays the indispensable physiological role. But, the physiological role of calumin is not clear.
To maintain ER homeostasis, ER is equipped with ERAD functioning as protein quality control system. This study suggests not only the importance of calumin in ERAD but also the significance of ERAD in visceral endoderm cells functioning as the very few secretory cells around the embryonic day when calumin-knockout mice die.

Research Products

• [Journal Article] TRIM50 regulates vesicular trafficking for acid secretion in gastric parietal cells. (2012)
  • Author(s): Nishi, M., Aoyama, F., Kisa, F., Zhu, H., Sun, M., Lin, P., Ohta, H., Yamamoto, S., Kakizawa, S., Sakai, H., Ma, J., Sawaguchi, A. & Takeshima, H.
  • Journal Title: J. Biol. Chem. Volume: 287 Issue: 40 Pages: 33523-33532
  • DOI: 10.1074/jbc.m112.370551
  • Peer Reviewed