Analysis for role of calumin in lipid transport of polarized cells

Research Project

Project/Area Number	24790073
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Biological pharmacy
Research Institution	Kyoto University
Principal Investigator	YAMAMOTO Shinichiro 京都大学, 薬学研究科(研究院), 助教 (10542102)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000) Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	ERAD / ER ストレス
Research Abstract	Calumin is a novel ER-resident protein. Disruption of calumin gene in mice causes embryonic lethality, suggesting that calumin plays the indispensable physiological role. But, the physiological role of calumin is not clear. To maintain ER homeostasis, ER is equipped with ERAD functioning as protein quality control system. This study suggests not only the importance of calumin in ERAD but also the significance of ERAD in visceral endoderm cells functioning as the very few secretory cells around the embryonic day when calumin-knockout mice die.

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(3 results)