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Regulation of inflammation by stress proteins

Research Project

Project/Area Number 24790077
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biological pharmacy
Research InstitutionKeio University (2013)
Kumamoto University (2012)

Principal Investigator

TANAKA Kenichiro  慶應義塾大学, 薬学部, 助教 (30555777)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsストレスタンパク質
Research Abstract

In this study, we have examined the role of HSP70 in gastric ulcer healing. Gastric ulcers were produced by focal and serosal application of acetic acid. Expression of HSP70 was induced in both the gastric ulcer margin and granulation tissue. Compared with wild-type mice, gastric ulcer healing was accelerated in transgenic mice expressing HSP70, and both cell proliferation at the gastric ulcer margin and angiogenesis in granulation tissue were enhanced. Oral administration of geranylgeranylacetone, an inducer of HSPs, to wild-type mice, either prior to or after ulcer formation, not only induced expression of HSP70 in the stomach but also accelerated gastric ulcer healing. On the other hand, oral administration of purified recombinant HSP70 prior to the ulcer formation, but not after formation, stimulated gastric ulcer healing. This study provides the first evidence that HSP70 accelerates gastric ulcer healing.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (16 results)

All 2014 2013 2012 Other

All Journal Article (16 results) (of which Peer Reviewed: 8 results)

  • [Journal Article] Superiority of pulmonary administration of mepenzolate bromide over other routes as treatment for chronic obstructive pulmonary disease2014

    • Author(s)
      Tanaka, K., Kurotsu, S., Asano, T., Yamakawa, N., Kobayashi D., Yamashita, Y., Yamazaki, H., Ishihara, T., Watanabe, H., Maruyama, T., Suzuki, H. and Mizushima, T
    • Journal Title

      Sci. Rep

      Volume: 28 Pages: 4510-4510

    • Related Report
      2013 Final Research Report
  • [Journal Article] Mepenzolate bromide displays beneficial effects in a mouse model of chronic obstructive pulmonary disease2013

    • Author(s)
      Tanaka, K., Ishihara, T., Sugizaki, T., Kobayashi D., Yamashita, Y., Tahara, K., Yamakawa, N., Iijima, K., Mogushi, K., Tanaka, H., Sato, K., Suzuki, H. and Mizushima, T
    • Journal Title

      Nature Communications

      Volume: 4 Pages: 2686-2686

    • Related Report
      2013 Final Research Report
  • [Journal Article] Long-acting human serum albumin-thioredoxin fusion protein suppresses bleomycin-induced pulmonary fibrosis progression.2013

    • Author(s)
      Tanaka R, Watanabe H, Kodama A, Chuang VT, Ishima Y, Hamasaki K, Tanaka K, Mizushima T, Otagiri M, Maruyama T.
    • Journal Title

      J Pharmacol Exp Ther.

      Volume: 345 Issue: 2 Pages: 271-283

    • DOI

      10.1124/jpet.112.201814

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of pharmacokinetics between loxoprofen and its derivative with lower ulcerogenic activity, fluoro-loxoprofen2013

    • Author(s)
      Yamakawa, N., Suemasu, S., Watanabe, H., Tahara, K., Tanaka, K., Okamoto, Y., Ohtsuka, M., Maruyama, T. and Mizushima, T
    • Journal Title

      Drug Metab. Pharmacokinet

      Volume: 28 Pages: 118-124

    • NAID

      130004933526

    • Related Report
      2013 Final Research Report
  • [Journal Article] Mepenzolate bromide displays beneficial effects in a mouse model of chronic obstructive pulmonary disease.2013

    • Author(s)
      Tanaka, K., Ishihara, T., Sugizaki, T., Kobayashi D., Yamashita, Y., Tahara, K., Yamakawa, N., Iijima, K., Mogushi, K., Tanaka, H., Sato, K., Suzuki, H. and Mizushima, T.
    • Journal Title

      Nature Communications

      Volume: 4 Pages: 2686-2686

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of 150-kDa oxygen-regulated protein (QRP150) stimulates bleomycin-induced pulmonary fibrosis and dysfunction in mice2012

    • Author(s)
      Tanaka, K., et al.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 425 Issue: 4 Pages: 818-824

    • DOI

      10.1016/j.bbrc.2012.07.158

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a unique nsaid, fluoro-loxoprofen with gastroprotective activity.2012

    • Author(s)
      Suemasu S., et al.
    • Journal Title

      Biochem Pharmacol.

      Volume: 84 Issue: 11 Pages: 1470-1481

    • DOI

      10.1016/j.bcp.2012.09.016

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of lecithinized superoxide dismutase and/or pirfenidone against bleomycin-induced pulmonary fibrosis2012

    • Author(s)
      Tanaka, K., Azuma, A., Miyazaki, Y., Sato, K. and Mizushima, T
    • Journal Title

      Chest

      Volume: 142 Pages: 1011-1019

    • Related Report
      2013 Final Research Report
  • [Journal Article] Synthesis and biological evaluation of derivatives of 2-{2-fluoro-4-[(2-oxocyclopentyl)methyl ]phenyl}propanoic acid : Non-steroidal anti-inflammatory drugs with low gastric ulcerogenic activity2012

    • Author(s)
      Yamakawa, N., Suemasu, S., Okamoto, Y., Tanaka, K., Ishihara, T., Asano, T., Miyata, k., Ohtsuka, M. and Mizushima, T
    • Journal Title

      J. Med. Chem

      Volume: 55 Pages: 5143-5150

    • Related Report
      2013 Final Research Report
  • [Journal Article] Superiority of PC-SOD to other anti-COPD drugs for elastase-induced emphysema and alteration in lung mechanics and respiratory function in mice2012

    • Author(s)
      Tanaka, K., Sato, K., Aoshiba, K., Azuma, A. and Mizushima, T.
    • Journal Title

      Am. J. Physiol. Lung Cell. Mol. Physiol.

      Volume: 302 Issue: 12 Pages: L1250-L1261

    • DOI

      10.1152/ajplung.00019.2012

    • Related Report
      2013 Final Research Report
  • [Journal Article] Effects of β-(1,3-1,6)-D-glucan on irritable bowel syndrome-related colonic hypersensitivity2012

    • Author(s)
      Asano, T., Suzuki, H., et al
    • Journal Title

      Biochem.Biophys.Res.Com.

      Volume: 420(2) Issue: 2 Pages: 444-449

    • DOI

      10.1016/j.bbrc.2012.03.015

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of β-(1,3-1,6)-D-glucan on irritable bowel syndrome-related colonic hypersensitivity.2012

    • Author(s)
      Asano. T. et al.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 420 Pages: 444-449

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Superiority of PC-SOD to other anti-COPD drugs for elastase-induced emphysema and alteration in lung mechanics and respiratory function in mice.2012

    • Author(s)
      Tanaka. K. et al.
    • Journal Title

      Am. J. Physiol. Lung Cell. Mol. Physiol.

      Volume: 302

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synthesis and biological evaluation of derivatives of 2-{2-fluoro-4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid: Non-steroidal anti-inflammatory drugs with low gastric ulcerogenic activity.2012

    • Author(s)
      Yamakawa. N. et al.
    • Journal Title

      J. Med. Chem.

      Volume: 55 Pages: 5143-5150

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synthesis and biological comparison of enantiomers of mepenzolate bromide, a muscarinic receptor antagonist with bronchodilatory and anti-inflammatory activities

    • Author(s)
      Yamashita, Y., Tanaka, K., Asano, T., Yamakawa, N., Kobayashi D., Ishihara, T., Hanaya, K., Shoji, M., Sugai, T., Wada, M., Mashimo, T., Fukunishi, Y. and Mizushima T
    • Journal Title

      Bioorg. & Medic. Chem

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Ameliorative effect of mepenzolate bromide against pulmonary fibrosis

    • Author(s)
      Kurotsu, S., Tanaka, K., Niino, T., Sugizaki, T., Azuma, A., Suzuki, H. and Mizushima, T
    • Journal Title

      J. Pharmacol. Exp. Ther

      Volume: (in press)

    • Related Report
      2013 Final Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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