Function of sialidase in hippocampal-dependent memory
Project/Area Number |
24790080
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Biological pharmacy
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Research Institution | University of Shizuoka |
Principal Investigator |
Minami Akira 静岡県立大学, 薬学部, 講師 (80438192)
|
Project Period (FY) |
2012-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | シアリダーゼ / イメージング / 蛍光プローブ / 記憶 / 海馬 / シアル酸 / N-グリコリルノイラミン酸 / ラット / 糖鎖 / ガングリオシド / オートラジオグラフィー / 組織染色 / 海馬依存性記憶 / 行動解析 / アイソザイム / 神経 / シナプス可塑性 / インビボ |
Outline of Final Research Achievements |
Sialidase removes sialic acid residues from sialoglycoconjugates such as glycoproteins and glycolipids. Since sialic acid plays crucial roles in synaptic plasticity and memory in the hippocampus, regulation of sialyl signaling by sialidase is also necessary for neural functions. In this projects, we found that sialidase is essential for hippocampal-dependent memory.
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Report
(5 results)
Research Products
(126 results)
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[Journal Article] Isolation and characterization of monoclonal antibodies specific for chondroitin sulfate E.2015
Author(s)
Watanabe I, Hikita T, Mizuno H, Sekita R, Minami A, Ishii A, Minamisawa Y, Suzuki K, Maeda H, Hidari KI, Suzuki T.
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Journal Title
Glycobiology
Volume: 25
Issue: 9
Pages: 953-962
DOI
Related Report
Peer Reviewed
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[Journal Article] Easy and Rapid Detection of Mumps Virus by Live Fluorescent Visualization of Virus-Infected Cells2015
Author(s)
Tadanobu Takahashi, Takashi Agarikuchi, Yuuki Kurebayashi, Nona Shibahara, Chihiro Suzuki, Akiko Kishikawa, Keijo Fukushima, Maiko Takano, Fumie Suzuki, Hirohisa Wada, Tadamune Otsubo, Kiyoshi Ikeda, Akira Minami, Takashi Suzuki
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Journal Title
PLoS One
Volume: 10
Issue: 12
Pages: e0144038-e0144038
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Amino acid substitutions contributing to α2,6-sialic acid linkage binding specificity of human parainfluenza virus type 3 hemagglutinin-neuraminidase.2015
Author(s)
Fukushima K, Takahashi T, Ueyama H, Takaguchi M, Ito S, Oishi K, Minami A, Ishitsubo E, Tokiwa H, Takimoto T, Suzuki T.
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Journal Title
FEBS Lett.
Volume: 589
Issue: 11
Pages: 1278-1282
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Imaging of influenza virus sialidase activity in living cells.2014
Author(s)
Yuuki Kurebayashi, Tadanobu Takahashi, Tadamune Otsubo, Kiyoshi Ikeda, Shunsaku Takahashi, Maiko Takano, Takashi Agarikuchi, Tsubasa Sato, Yukino Matsuda, Akira Minami, Hiroaki Kanazawa, Yuko Uchida, Takehiko Saito, Yoshihiro Kawaoka, Toshihiro Yamada, Fumihiko Kawamori, Robin Thomson, Mark von Itzstein, Takashi Suzuki
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Journal Title
Sci. Rep.
Volume: 4
Issue: 1
Pages: 4877-4877
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] N-glycolylneuraminic Acid on Human Epithelial Cells Prevents Entry of Influenza A Virus with N-glycolylneuraminic Acid Binding Ability.2014
Author(s)
Tadanobu Takahashi, Maiko Takano, Yuuki Kurebayashi, Midori Masuda, Sawako Kawagishi, Masahiro Takaguchi, Takashi Yamanaka, Akira Minami, Tadamune Otsubo, Kiyoshi Ikeda, Takashi Suzuki
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Journal Title
J. Virol.
Volume: 88
Issue: 15
Pages: 8445-8456
DOI
Related Report
Peer Reviewed
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[Journal Article] Terminal sialic acid linkages determine different cell infectivities of human parainfluenza virus type 1 and type 32014
Author(s)
Fukushima K, Takahashi T, Ito S, Takaguchi M, Takano M, Kurebayashi Y, Oishi K, Minami A, Kato T, Park EY, Nishimura H, Takimoto T, Suzuki T.
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Journal Title
Virology
Volume: 464-465
Pages: 424-431
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Visualization of sialidase activity in mammalian tissues and cancer detection with a novel fluorescent sialidase substrate.2014
Author(s)
Akira Minami, Tadamune Otsubo, Daisuke Ieno, Kiyoshi Ikeda, Hiroaki Kanazawa, Kosuke Shimizu, Ko Ohata, Tsunehiro Yokochi, Yuuki Horii, Hokuto Fukumoto, Risa Taguchi, Tadanobu Takahashi, Naoto Oku, Takashi Suzuki.
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Journal Title
PLoS One
Volume: 9
Issue: 1
Pages: e81941-e81941
DOI
Related Report
Peer Reviewed
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[Journal Article] Improvement of Depression-Like Behavior and Memory Impairment with the Ethanol Extract of <i>Pleurotus eryngii</i> in Ovariectomized Rats2013
Author(s)
Akira Minami, Hiroshi Matsushita, Yuuki Horii, Daisuke Ieno, Yukino Matsuda, Masakazu Saito, Hiroaki Kanazawa, Yuriko Ohyama, Akihiko Wakatsuki, Atsushi Takeda, Kazuya I.P.J. Hidari, Vikineswary Sabaratnam, and Takashi Suzuki
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Journal Title
Biological and Pharmaceutical Bulletin
Volume: 36
Issue: 12
Pages: 1990-1995
DOI
NAID
ISSN
0918-6158, 1347-5215
Related Report
Peer Reviewed
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[Journal Article] Sensitive and direct detection of receptor binding specificity of highly pathogenic avian influenza A virus in clinical samples.2013
Author(s)
Tadanobu Takahashi, Tatsuya Kawakami, Takashi Mizuno, Akira Minami, Yuko Uchida, Takehiko Saito, Shigeyuki Matsui, Makoto Ogata, Taichi Usui, Nongluk Sriwilaijaroen, Hiroaki Hiramatsu, Yasuo Suzuki, Takashi Suzuki.
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Journal Title
PLoS One
Volume: 8
Issue: 10
Pages: e78125-e78125
DOI
Related Report
Peer Reviewed
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[Journal Article] Catalytic preference of Salmonella typhimurium LT2 sialidase for N-acetylneuraminic acid residue over N-glycolylneuraminic acid residue2013
Author(s)
Akira Minami, Sayaka Ishibashi, Kiyoshi Ikeda, Erika Ishitsubo, Hiroaki Tokiwa, Risa Taguchi, Daisuke Ieno, Tadamune Otsubo, Yukino Matsuda, Saki Sai, Mari Inada and Takashi Suzuki
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Journal Title
Related Report
Peer Reviewed
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[Presentation] Histochemical Fluorescent Visualization of Influenza Virus Sialidase activity.2014
Author(s)
Tadanobu Takahashi, Yuuki Kurebayashi, Tadamune Otsubo, Kiyoshi Ikeda, Shunsaku Takahashi, Maiko Takano, Takashi Agarikuchi, Tsubasa Sato, Yukino Matsuda, Akira Minami, Hiroaki Kanazawa, Yuko Uchida, Takehiko Saito, Yoshihiro Kawaoka, Toshihiro Yamada, Fumihiko Kawamori, Robin Thomson, Mark von Itzstein, Takashi Suzuki
Organizer
The 11th Japan-China International Symposium on Health Sciences
Place of Presentation
Shizuoka
Year and Date
2014-11-05
Related Report
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[Presentation] 新規シアリダーゼ活性検出用プローブを利用した組織染色2013
Author(s)
南 彰, 大坪 忠宗, 家野 太輔, 池田 潔, 金澤 寛明, 清水 広介, 大端 考、横地 常広、堀井 雄樹, 福元 北斗, 田口 理紗, 石橋 さやか, 高橋 忠伸, 奥 直人, 鈴木 隆
Organizer
第86回日本生化学会大会
Place of Presentation
横浜
Related Report
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[Presentation] Visualization of sialidase activity in mammalian tissues and cancer detection with a novel fluorescent sialidase substrate
Author(s)
Daisuke Ieno, Akira Minami, Tadamune Otsubo, Kiyoshi Ikeda, Hiroaki Kanazawa, Kosuke Shimizu, Ko Ohata, Tsunehiro Yokochi, Yuuki Horii, Hokuto Fukumoto, Risa Taguchi, Tadanobu Takahashi, Naoto Oku, Takashi Suzuki
Organizer
第18回 静岡・健康長寿学術フォーラム
Place of Presentation
静岡
Related Report
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[Presentation] 新規シアリダーゼ活性染色用蛍光プローブの開発と評価
Author(s)
堀井 雄樹, 南 彰, 大坪 忠宗, 家野 太輔, 池田 潔, 金澤 寛明, 清水 広介, 福元 北斗, 田口 理紗, 石橋 さやか, 高橋 忠伸, 奥 直人, 鈴木 隆
Organizer
第77回日本生化学会中部支部会例
Place of Presentation
名古屋
Related Report
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[Presentation] 新規シアリダーゼ活性検出プローブによる大腸癌検出
Author(s)
南 彰, 大坪 忠宗, 家野 太輔, 池田 潔, 金澤 寛明, 清水 広介, 大端 考、横地 常広、堀井 雄樹, 福元 北斗, 田口 理紗, 石橋 さやか, 高橋 忠伸, 奥 直人, 鈴木 隆
Organizer
第59回日本薬学会東海支部 総会・大会
Place of Presentation
名古屋
Related Report
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