Brain pericytes induce the brain inflammation that derived from chronic peripheral inflammation in diabetic mellitus via PAR-1 signal
| Project/Area Number |
24790102
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 薬理学 / 脳内炎症 / 糖尿病 / 脳ペリサイト / トロンビン |
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| Research Abstract |
In diabetic mellitus, inflammation is observed in the brain as well as the peripheral and contributes to the pathogenesis of diabetic cognitive dysfunction. This study aimed to clarify the involvement of thrombin-responsive brain pericytes in the propagation mechanism of inflammation from the peripheral to the brain. Increase the amount of thrombin was observed in the brain of high-fat diet induced obesity and glucose-intolerance model mouse. Further, thrombin-treated brain pericytes enhanced the permeability of the blood-brain barrier, and released matrix metalloproteinase-9. These results suggest that thrombin-responsive brain pericytes have an important role in the formation of brain inflammation in diabetic mellitus.
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Report
(3 results)
Research Products
(2 results)
