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Investigation of the thrombospondin-1 as a novel therapeutic target molecule for depression.

Research Project

Project/Area Number 24790106
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biological pharmacy
Research InstitutionDepartment of Clinical Research, National Hospital Organization Kure Medical Center

Principal Investigator

OKADA-TSUCHIOKA Mami  独立行政法人国立病院機構(呉医療センター臨床研究部), その他部局等, 研究員 (30517280)

Project Period (FY) 2013-02-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsシナプス新生 / 電気けいれん療法 / アストロサイト / thrombospondin-1 / Thrombospondin-1
Outline of Final Research Achievements

In this study, I have focused on thrombospondin-1 (TSP-1), an astrocyte-derived synaptogenic factor, as a novel therapeutic target for depression. I have investigated the effects of electroconvulsive seizure (ECS), an animal model of electroconvulsive therapy (ECT), and chronic treatment with antidepressants on the expression of TSP-1 in the adult rat hippocampus. I have revealed that repeated ECS, but not chronic treatment with antidepressants, induced TSP-1 expression partially via the activation of astrocytes. Therefore, TSP-1 is possibly involved in the effects of ECT (Okada-Tsuchioka M et al., 2014).

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (3 results)

All 2014 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Electroconvulsive seizure induces thrombospondin-1 in the adult rat hippocampus.2014

    • Author(s)
      Mami Okada-Tsuchioka, Masahiro Segawa, Naoto Kajitani, Kazue Hisaoka-Nakashima, Chiyo Shibasaki, Shigeru Morinobu, Minoru Takebayashi
    • Journal Title

      Progress in Neuro-Psychopharmacology & Biological Psychiatry

      Volume: 48 Pages: 236-244

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] How does electroconvulsive therapy work for depression? -Involvement of astrocyte-derived synaptogenic factor, thrombospondin-1-2014

    • Author(s)
      Mami Okada-Tsuchioka, Naoto Kajitani, Hiromi Abe, Chiyo Shibasaki, Minoru Takebayashi
    • Organizer
      The 7th Kure International Medical Forum (K-INT) in 2014
    • Place of Presentation
      Convention Hall, National Hospital Organization, Kure Medical Center Chugoku Cancer Center
    • Year and Date
      2014-07-10 – 2014-07-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 電気けいれん刺激(ECS)は成体ラット海馬においてシナプス新生作用を有するアストロサイト分泌性thrombospondin-1(TSP-1)を誘導する2013

    • Author(s)
      岡田(土岡)麻美、瀬川昌弘、梶谷直人、柴崎千代、安部裕美、中島(久岡)一恵、森信 繁、竹林 実
    • Organizer
      第23回日本臨床精神神経薬理学会・第43回日本神経精神薬理学会合同年会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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