| Project/Area Number |
24790119
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 虚血／再灌流障害 / HCV / フォールディング / ダントロレン / 虚血・再灌流障害 / ミトコンドリア / C型肝炎 / 虚血性疾患 / PTP |
|---|
| Research Abstract |
In this study, we tried to establish innovative drug development methodology by using a basic medicinal chemistry based on behavioral structure-building regulation of protein. A target of this study is folding regulatory factor, and illness to intend for both ischemia/reperfusion induced cell death and hepatitis C virus reproduction. As a result, we succeeded in development of compounds which have inhibitory effect of Ca2+-induced mitochondrial swelling. These compounds were considered to be capable of inhibitor for the ischemia/reperfusion induced cell death.
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